CCDC148 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBX1	CCDC148	ENSP00000377060	ENSP00000283233	Chromobox protein homolog 1; Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.	Coiled-coil domain containing 148.	0.456
CCDC148	CBX1	ENSP00000283233	ENSP00000377060	Coiled-coil domain containing 148.	Chromobox protein homolog 1; Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.	0.456
CCDC148	GOLGB1	ENSP00000283233	ENSP00000377275	Coiled-coil domain containing 148.	Golgin subfamily B member 1; May participate in forming intercisternal cross-bridges of the Golgi complex.	0.613
CCDC148	LACRT	ENSP00000283233	ENSP00000257867	Coiled-coil domain containing 148.	Extracellular glycoprotein lacritin; Modulates secretion by lacrimal acinar cells.	0.600
CCDC148	LRRC49	ENSP00000283233	ENSP00000453273	Coiled-coil domain containing 148.	Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49.	0.533
CCDC148	LTF	ENSP00000283233	ENSP00000231751	Coiled-coil domain containing 148.	Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection. N-terminal region shows strong antifungal activity against C.albicans. Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG- binding site. Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows pr [...]	0.614
CCDC148	QRICH2	ENSP00000283233	ENSP00000262765	Coiled-coil domain containing 148.	Glutamine-rich protein 2; Has an essential role in the formation of sperm flagella and flagellar structure maintainance. It acts as a suppressor of ubiquitination and degradation of proteins involved in flagellar development and motility.	0.496
CCDC148	SAT1	ENSP00000283233	ENSP00000368572	Coiled-coil domain containing 148.	Diamine acetyltransferase 1; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)- acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine; Belongs to the acetyltransferase family.	0.696
CCDC148	SCGB1D1	ENSP00000283233	ENSP00000303070	Coiled-coil domain containing 148.	Secretoglobin family 1D member 1; May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.	0.682
CCDC148	SCGB2A1	ENSP00000283233	ENSP00000244930	Coiled-coil domain containing 148.	Mammaglobin-B; May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.	0.599
CCDC148	TEX9	ENSP00000283233	ENSP00000342169	Coiled-coil domain containing 148.	Testis-expressed protein 9; Testis expressed 9.	0.809
GOLGB1	CCDC148	ENSP00000377275	ENSP00000283233	Golgin subfamily B member 1; May participate in forming intercisternal cross-bridges of the Golgi complex.	Coiled-coil domain containing 148.	0.613
LACRT	CCDC148	ENSP00000257867	ENSP00000283233	Extracellular glycoprotein lacritin; Modulates secretion by lacrimal acinar cells.	Coiled-coil domain containing 148.	0.600
LACRT	LTF	ENSP00000257867	ENSP00000231751	Extracellular glycoprotein lacritin; Modulates secretion by lacrimal acinar cells.	Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection. N-terminal region shows strong antifungal activity against C.albicans. Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG- binding site. Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows pr [...]	0.613
LACRT	SCGB1D1	ENSP00000257867	ENSP00000303070	Extracellular glycoprotein lacritin; Modulates secretion by lacrimal acinar cells.	Secretoglobin family 1D member 1; May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.	0.870
LACRT	SCGB2A1	ENSP00000257867	ENSP00000244930	Extracellular glycoprotein lacritin; Modulates secretion by lacrimal acinar cells.	Mammaglobin-B; May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.	0.795
LRRC49	CCDC148	ENSP00000453273	ENSP00000283233	Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49.	Coiled-coil domain containing 148.	0.533
LTF	CCDC148	ENSP00000231751	ENSP00000283233	Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection. N-terminal region shows strong antifungal activity against C.albicans. Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG- binding site. Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows pr [...]	Coiled-coil domain containing 148.	0.614
LTF	LACRT	ENSP00000231751	ENSP00000257867	Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection. N-terminal region shows strong antifungal activity against C.albicans. Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG- binding site. Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows pr [...]	Extracellular glycoprotein lacritin; Modulates secretion by lacrimal acinar cells.	0.613
LTF	SCGB1D1	ENSP00000231751	ENSP00000303070	Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection. N-terminal region shows strong antifungal activity against C.albicans. Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG- binding site. Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows pr [...]	Secretoglobin family 1D member 1; May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.	0.411