node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADGRA1 | ADGRF4 | ENSP00000376384 | ENSP00000283303 | Adhesion G protein-coupled receptor A1; Orphan receptor. | Adhesion G protein-coupled receptor F4; Orphan receptor. | 0.594 |
ADGRA2 | ADGRF4 | ENSP00000406367 | ENSP00000283303 | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. ADGRA2-tethering function does not rely [...] | Adhesion G protein-coupled receptor F4; Orphan receptor. | 0.492 |
ADGRA3 | ADGRF4 | ENSP00000334952 | ENSP00000283303 | Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | Adhesion G protein-coupled receptor F4; Orphan receptor. | 0.511 |
ADGRF4 | ADGRA1 | ENSP00000283303 | ENSP00000376384 | Adhesion G protein-coupled receptor F4; Orphan receptor. | Adhesion G protein-coupled receptor A1; Orphan receptor. | 0.594 |
ADGRF4 | ADGRA2 | ENSP00000283303 | ENSP00000406367 | Adhesion G protein-coupled receptor F4; Orphan receptor. | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. ADGRA2-tethering function does not rely [...] | 0.492 |
ADGRF4 | ADGRA3 | ENSP00000283303 | ENSP00000334952 | Adhesion G protein-coupled receptor F4; Orphan receptor. | Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | 0.511 |
ADGRF4 | C5orf46 | ENSP00000283303 | ENSP00000315370 | Adhesion G protein-coupled receptor F4; Orphan receptor. | Uncharacterized protein C5orf46; Chromosome 5 open reading frame 46. | 0.457 |
ADGRF4 | CD2AP | ENSP00000283303 | ENSP00000352264 | Adhesion G protein-coupled receptor F4; Orphan receptor. | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glom [...] | 0.411 |
ADGRF4 | GPR87 | ENSP00000283303 | ENSP00000260843 | Adhesion G protein-coupled receptor F4; Orphan receptor. | G-protein coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage. Belongs to the G-protein coupled receptor 1 family. | 0.414 |
ADGRF4 | WFDC5 | ENSP00000283303 | ENSP00000361875 | Adhesion G protein-coupled receptor F4; Orphan receptor. | WAP four-disulfide core domain protein 5; Putative acid-stable proteinase inhibitor. | 0.459 |
C5orf46 | ADGRF4 | ENSP00000315370 | ENSP00000283303 | Uncharacterized protein C5orf46; Chromosome 5 open reading frame 46. | Adhesion G protein-coupled receptor F4; Orphan receptor. | 0.457 |
C5orf46 | GPR87 | ENSP00000315370 | ENSP00000260843 | Uncharacterized protein C5orf46; Chromosome 5 open reading frame 46. | G-protein coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage. Belongs to the G-protein coupled receptor 1 family. | 0.468 |
C5orf46 | WFDC5 | ENSP00000315370 | ENSP00000361875 | Uncharacterized protein C5orf46; Chromosome 5 open reading frame 46. | WAP four-disulfide core domain protein 5; Putative acid-stable proteinase inhibitor. | 0.581 |
CD2AP | ADGRF4 | ENSP00000352264 | ENSP00000283303 | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glom [...] | Adhesion G protein-coupled receptor F4; Orphan receptor. | 0.411 |
GPR87 | ADGRF4 | ENSP00000260843 | ENSP00000283303 | G-protein coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage. Belongs to the G-protein coupled receptor 1 family. | Adhesion G protein-coupled receptor F4; Orphan receptor. | 0.414 |
GPR87 | C5orf46 | ENSP00000260843 | ENSP00000315370 | G-protein coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage. Belongs to the G-protein coupled receptor 1 family. | Uncharacterized protein C5orf46; Chromosome 5 open reading frame 46. | 0.468 |
GPR87 | WFDC5 | ENSP00000260843 | ENSP00000361875 | G-protein coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage. Belongs to the G-protein coupled receptor 1 family. | WAP four-disulfide core domain protein 5; Putative acid-stable proteinase inhibitor. | 0.555 |
WFDC5 | ADGRF4 | ENSP00000361875 | ENSP00000283303 | WAP four-disulfide core domain protein 5; Putative acid-stable proteinase inhibitor. | Adhesion G protein-coupled receptor F4; Orphan receptor. | 0.459 |
WFDC5 | C5orf46 | ENSP00000361875 | ENSP00000315370 | WAP four-disulfide core domain protein 5; Putative acid-stable proteinase inhibitor. | Uncharacterized protein C5orf46; Chromosome 5 open reading frame 46. | 0.581 |
WFDC5 | GPR87 | ENSP00000361875 | ENSP00000260843 | WAP four-disulfide core domain protein 5; Putative acid-stable proteinase inhibitor. | G-protein coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage. Belongs to the G-protein coupled receptor 1 family. | 0.555 |