node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COG3 | COG6 | ENSP00000258654 | ENSP00000397441 | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family. | 0.999 |
COG3 | VILL | ENSP00000258654 | ENSP00000283713 | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | Villin-like protein; Possible tumor suppressor. | 0.449 |
COG6 | COG3 | ENSP00000397441 | ENSP00000258654 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family. | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | 0.999 |
COG6 | VILL | ENSP00000397441 | ENSP00000283713 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family. | Villin-like protein; Possible tumor suppressor. | 0.499 |
CTDSPL | SLC22A14 | ENSP00000273179 | ENSP00000273173 | CTD small phosphatase-like protein; Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. | Solute carrier family 22 member 14; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | 0.405 |
CTDSPL | VILL | ENSP00000273179 | ENSP00000283713 | CTD small phosphatase-like protein; Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. | Villin-like protein; Possible tumor suppressor. | 0.494 |
DLEC1 | PLCD1 | ENSP00000308597 | ENSP00000430344 | Deleted in lung and esophageal cancer protein 1; May act as a tumor suppressor by inhibiting cell proliferation. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. | 0.766 |
DLEC1 | SLC22A14 | ENSP00000308597 | ENSP00000273173 | Deleted in lung and esophageal cancer protein 1; May act as a tumor suppressor by inhibiting cell proliferation. | Solute carrier family 22 member 14; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | 0.435 |
DLEC1 | VILL | ENSP00000308597 | ENSP00000283713 | Deleted in lung and esophageal cancer protein 1; May act as a tumor suppressor by inhibiting cell proliferation. | Villin-like protein; Possible tumor suppressor. | 0.423 |
PLCD1 | DLEC1 | ENSP00000430344 | ENSP00000308597 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. | Deleted in lung and esophageal cancer protein 1; May act as a tumor suppressor by inhibiting cell proliferation. | 0.766 |
PLCD1 | VILL | ENSP00000430344 | ENSP00000283713 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. | Villin-like protein; Possible tumor suppressor. | 0.422 |
SLC22A14 | CTDSPL | ENSP00000273173 | ENSP00000273179 | Solute carrier family 22 member 14; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | CTD small phosphatase-like protein; Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. | 0.405 |
SLC22A14 | DLEC1 | ENSP00000273173 | ENSP00000308597 | Solute carrier family 22 member 14; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | Deleted in lung and esophageal cancer protein 1; May act as a tumor suppressor by inhibiting cell proliferation. | 0.435 |
SLC22A14 | VILL | ENSP00000273173 | ENSP00000283713 | Solute carrier family 22 member 14; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. | Villin-like protein; Possible tumor suppressor. | 0.527 |
SVIL | VILL | ENSP00000348128 | ENSP00000283713 | Supervillin; [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. | Villin-like protein; Possible tumor suppressor. | 0.413 |
TBC1D14 | VILL | ENSP00000386921 | ENSP00000283713 | TBC1 domain family member 14; Plays a role in the regulation of starvation-induced autophagosome formation. Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy. | Villin-like protein; Possible tumor suppressor. | 0.610 |
VILL | COG3 | ENSP00000283713 | ENSP00000258654 | Villin-like protein; Possible tumor suppressor. | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | 0.449 |
VILL | COG6 | ENSP00000283713 | ENSP00000397441 | Villin-like protein; Possible tumor suppressor. | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family. | 0.499 |
VILL | CTDSPL | ENSP00000283713 | ENSP00000273179 | Villin-like protein; Possible tumor suppressor. | CTD small phosphatase-like protein; Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. | 0.494 |
VILL | DLEC1 | ENSP00000283713 | ENSP00000308597 | Villin-like protein; Possible tumor suppressor. | Deleted in lung and esophageal cancer protein 1; May act as a tumor suppressor by inhibiting cell proliferation. | 0.423 |