node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C3orf52 | C4orf19 | ENSP00000399392 | ENSP00000371408 | TPA-induced transmembrane protein; Chromosome 3 open reading frame 52. | Uncharacterized protein C4orf19; Chromosome 4 open reading frame 19. | 0.429 |
C4orf19 | C3orf52 | ENSP00000371408 | ENSP00000399392 | Uncharacterized protein C4orf19; Chromosome 4 open reading frame 19. | TPA-induced transmembrane protein; Chromosome 3 open reading frame 52. | 0.429 |
C4orf19 | EIF3E | ENSP00000371408 | ENSP00000220849 | Uncharacterized protein C4orf19; Chromosome 4 open reading frame 19. | Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl- tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | 0.623 |
C4orf19 | FAM219B | ENSP00000371408 | ENSP00000350260 | Uncharacterized protein C4orf19; Chromosome 4 open reading frame 19. | Protein FAM219B; Family with sequence similarity 219 member B. | 0.432 |
C4orf19 | FAM221A | ENSP00000371408 | ENSP00000342576 | Uncharacterized protein C4orf19; Chromosome 4 open reading frame 19. | Protein FAM221A; Family with sequence similarity 221 member A; Belongs to the FAM221 family. | 0.458 |
C4orf19 | KIAA0930 | ENSP00000371408 | ENSP00000251993 | Uncharacterized protein C4orf19; Chromosome 4 open reading frame 19. | Uncharacterized protein KIAA0930; KIAA0930. | 0.447 |
C4orf19 | LRRC66 | ENSP00000371408 | ENSP00000341944 | Uncharacterized protein C4orf19; Chromosome 4 open reading frame 19. | Leucine-rich repeat-containing protein 66; Leucine rich repeat containing 66. | 0.436 |
C4orf19 | PDCD10 | ENSP00000371408 | ENSP00000376506 | Uncharacterized protein C4orf19; Chromosome 4 open reading frame 19. | Programmed cell death protein 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Belongs to the PDCD10 family. | 0.861 |
C4orf19 | STK24 | ENSP00000371408 | ENSP00000365730 | Uncharacterized protein C4orf19; Chromosome 4 open reading frame 19. | Serine/threonine-protein kinase 24 12 kDa subunit; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr [...] | 0.834 |
C4orf19 | STK25 | ENSP00000371408 | ENSP00000325748 | Uncharacterized protein C4orf19; Chromosome 4 open reading frame 19. | Serine/threonine-protein kinase 25; Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. | 0.832 |
C4orf19 | STK26 | ENSP00000371408 | ENSP00000377867 | Uncharacterized protein C4orf19; Chromosome 4 open reading frame 19. | Serine/threonine-protein kinase 26; Mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. | 0.827 |
EIF3E | C4orf19 | ENSP00000220849 | ENSP00000371408 | Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl- tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | Uncharacterized protein C4orf19; Chromosome 4 open reading frame 19. | 0.623 |
FAM219B | C4orf19 | ENSP00000350260 | ENSP00000371408 | Protein FAM219B; Family with sequence similarity 219 member B. | Uncharacterized protein C4orf19; Chromosome 4 open reading frame 19. | 0.432 |
FAM219B | FAM221A | ENSP00000350260 | ENSP00000342576 | Protein FAM219B; Family with sequence similarity 219 member B. | Protein FAM221A; Family with sequence similarity 221 member A; Belongs to the FAM221 family. | 0.479 |
FAM221A | C4orf19 | ENSP00000342576 | ENSP00000371408 | Protein FAM221A; Family with sequence similarity 221 member A; Belongs to the FAM221 family. | Uncharacterized protein C4orf19; Chromosome 4 open reading frame 19. | 0.458 |
FAM221A | FAM219B | ENSP00000342576 | ENSP00000350260 | Protein FAM221A; Family with sequence similarity 221 member A; Belongs to the FAM221 family. | Protein FAM219B; Family with sequence similarity 219 member B. | 0.479 |
KIAA0930 | C4orf19 | ENSP00000251993 | ENSP00000371408 | Uncharacterized protein KIAA0930; KIAA0930. | Uncharacterized protein C4orf19; Chromosome 4 open reading frame 19. | 0.447 |
LRRC66 | C4orf19 | ENSP00000341944 | ENSP00000371408 | Leucine-rich repeat-containing protein 66; Leucine rich repeat containing 66. | Uncharacterized protein C4orf19; Chromosome 4 open reading frame 19. | 0.436 |
PDCD10 | C4orf19 | ENSP00000376506 | ENSP00000371408 | Programmed cell death protein 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Belongs to the PDCD10 family. | Uncharacterized protein C4orf19; Chromosome 4 open reading frame 19. | 0.861 |
PDCD10 | STK24 | ENSP00000376506 | ENSP00000365730 | Programmed cell death protein 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Belongs to the PDCD10 family. | Serine/threonine-protein kinase 24 12 kDa subunit; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr [...] | 0.999 |