node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AREL1 | FAM161B | ENSP00000348714 | ENSP00000499021 | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation. | FAM161 centrosomal protein B; Belongs to the FAM161 family. | 0.484 |
AREL1 | LRRC74A | ENSP00000348714 | ENSP00000377369 | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation. | Leucine-rich repeat-containing protein 74A; Leucine rich repeat containing 74A. | 0.505 |
AZGP1 | FAM161B | ENSP00000292401 | ENSP00000499021 | Zinc-alpha-2-glycoprotein; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids; Belongs to the MHC class I family. | FAM161 centrosomal protein B; Belongs to the FAM161 family. | 0.509 |
CFAP36 | FAM161B | ENSP00000342699 | ENSP00000499021 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | FAM161 centrosomal protein B; Belongs to the FAM161 family. | 0.621 |
ENTPD5 | FAM161B | ENSP00000335246 | ENSP00000499021 | Ectonucleoside triphosphate diphosphohydrolase 5; Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thia [...] | FAM161 centrosomal protein B; Belongs to the FAM161 family. | 0.628 |
FAM161B | AREL1 | ENSP00000499021 | ENSP00000348714 | FAM161 centrosomal protein B; Belongs to the FAM161 family. | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation. | 0.484 |
FAM161B | AZGP1 | ENSP00000499021 | ENSP00000292401 | FAM161 centrosomal protein B; Belongs to the FAM161 family. | Zinc-alpha-2-glycoprotein; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids; Belongs to the MHC class I family. | 0.509 |
FAM161B | CFAP36 | ENSP00000499021 | ENSP00000342699 | FAM161 centrosomal protein B; Belongs to the FAM161 family. | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | 0.621 |
FAM161B | ENTPD5 | ENSP00000499021 | ENSP00000335246 | FAM161 centrosomal protein B; Belongs to the FAM161 family. | Ectonucleoside triphosphate diphosphohydrolase 5; Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thia [...] | 0.628 |
FAM161B | LIN52 | ENSP00000499021 | ENSP00000451812 | FAM161 centrosomal protein B; Belongs to the FAM161 family. | Protein lin-52 homolog; Lin-52 DREAM MuvB core complex component. | 0.494 |
FAM161B | LRRC74A | ENSP00000499021 | ENSP00000377369 | FAM161 centrosomal protein B; Belongs to the FAM161 family. | Leucine-rich repeat-containing protein 74A; Leucine rich repeat containing 74A. | 0.697 |
FAM161B | OIP5 | ENSP00000499021 | ENSP00000220514 | FAM161 centrosomal protein B; Belongs to the FAM161 family. | Protein Mis18-beta; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis; Belongs to the mis18 family. | 0.591 |
FAM161B | PTGR2 | ENSP00000499021 | ENSP00000452280 | FAM161 centrosomal protein B; Belongs to the FAM161 family. | Prostaglandin reductase 2; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity); Belongs to the NADP-dependent oxidoreductase L4BD family. | 0.510 |
FAM161B | SYCE1 | ENSP00000499021 | ENSP00000303978 | FAM161 centrosomal protein B; Belongs to the FAM161 family. | Synaptonemal complex central element protein 1; Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination. | 0.591 |
FAM161B | USH1G | ENSP00000499021 | ENSP00000480279 | FAM161 centrosomal protein B; Belongs to the FAM161 family. | Usher syndrome type-1G protein; Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. | 0.591 |
LIN52 | FAM161B | ENSP00000451812 | ENSP00000499021 | Protein lin-52 homolog; Lin-52 DREAM MuvB core complex component. | FAM161 centrosomal protein B; Belongs to the FAM161 family. | 0.494 |
LIN52 | LRRC74A | ENSP00000451812 | ENSP00000377369 | Protein lin-52 homolog; Lin-52 DREAM MuvB core complex component. | Leucine-rich repeat-containing protein 74A; Leucine rich repeat containing 74A. | 0.505 |
LRRC74A | AREL1 | ENSP00000377369 | ENSP00000348714 | Leucine-rich repeat-containing protein 74A; Leucine rich repeat containing 74A. | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation. | 0.505 |
LRRC74A | FAM161B | ENSP00000377369 | ENSP00000499021 | Leucine-rich repeat-containing protein 74A; Leucine rich repeat containing 74A. | FAM161 centrosomal protein B; Belongs to the FAM161 family. | 0.697 |
LRRC74A | LIN52 | ENSP00000377369 | ENSP00000451812 | Leucine-rich repeat-containing protein 74A; Leucine rich repeat containing 74A. | Protein lin-52 homolog; Lin-52 DREAM MuvB core complex component. | 0.505 |