node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTSL3 | ASTN2 | ENSP00000286744 | ENSP00000354504 | ADAMTS-like protein 3; ADAMTS like 3. | Astrotactin-2; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5- bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5- tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup. | 0.998 |
ADAMTSL3 | FRK | ENSP00000286744 | ENSP00000476145 | ADAMTS-like protein 3; ADAMTS like 3. | Tyrosine-protein kinase FRK; Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. | 0.792 |
ADAMTSL3 | HSD17B11 | ENSP00000286744 | ENSP00000351035 | ADAMTS-like protein 3; ADAMTS like 3. | Estradiol 17-beta-dehydrogenase 11; Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A- dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma. | 0.546 |
ADAMTSL3 | KIAA1328 | ENSP00000286744 | ENSP00000280020 | ADAMTS-like protein 3; ADAMTS like 3. | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. | 0.999 |
ADAMTSL3 | MAB21L3 | ENSP00000286744 | ENSP00000358512 | ADAMTS-like protein 3; ADAMTS like 3. | Protein mab-21-like 3; Mab-21 like 3. | 0.631 |
ADAMTSL3 | MIPOL1 | ENSP00000286744 | ENSP00000333539 | ADAMTS-like protein 3; ADAMTS like 3. | Mirror-image polydactyly 1. | 0.999 |
ADAMTSL3 | RPAP2 | ENSP00000286744 | ENSP00000476948 | ADAMTS-like protein 3; ADAMTS like 3. | Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2; Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes; Belongs to the RPAP2 family. | 0.668 |
ADAMTSL3 | TBC1D8B | ENSP00000286744 | ENSP00000349781 | ADAMTS-like protein 3; ADAMTS like 3. | TBC1 domain family member 8B; Involved in vesicular recycling, probably as a RAB11B GTPase- activating protein. | 0.513 |
ADAMTSL3 | TMEM212 | ENSP00000286744 | ENSP00000334072 | ADAMTS-like protein 3; ADAMTS like 3. | Transmembrane protein 212. | 0.762 |
ADAMTSL3 | WDPCP | ENSP00000286744 | ENSP00000272321 | ADAMTS-like protein 3; ADAMTS like 3. | WD repeat-containing and planar cell polarity effector protein fritz homolog; Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity). | 0.776 |
ASTN2 | ADAMTSL3 | ENSP00000354504 | ENSP00000286744 | Astrotactin-2; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5- bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5- tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup. | ADAMTS-like protein 3; ADAMTS like 3. | 0.998 |
ASTN2 | FRK | ENSP00000354504 | ENSP00000476145 | Astrotactin-2; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5- bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5- tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup. | Tyrosine-protein kinase FRK; Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. | 0.999 |
ASTN2 | KIAA1328 | ENSP00000354504 | ENSP00000280020 | Astrotactin-2; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5- bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5- tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup. | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. | 0.999 |
ASTN2 | MAB21L3 | ENSP00000354504 | ENSP00000358512 | Astrotactin-2; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5- bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5- tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup. | Protein mab-21-like 3; Mab-21 like 3. | 0.430 |
ASTN2 | MIPOL1 | ENSP00000354504 | ENSP00000333539 | Astrotactin-2; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5- bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5- tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup. | Mirror-image polydactyly 1. | 0.999 |
ASTN2 | RPAP2 | ENSP00000354504 | ENSP00000476948 | Astrotactin-2; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5- bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5- tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup. | Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2; Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes; Belongs to the RPAP2 family. | 0.810 |
ASTN2 | TBC1D8B | ENSP00000354504 | ENSP00000349781 | Astrotactin-2; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5- bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5- tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup. | TBC1 domain family member 8B; Involved in vesicular recycling, probably as a RAB11B GTPase- activating protein. | 0.442 |
ASTN2 | TMEM212 | ENSP00000354504 | ENSP00000334072 | Astrotactin-2; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5- bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5- tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup. | Transmembrane protein 212. | 0.485 |
ASTN2 | WDPCP | ENSP00000354504 | ENSP00000272321 | Astrotactin-2; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5- bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5- tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup. | WD repeat-containing and planar cell polarity effector protein fritz homolog; Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity). | 0.819 |
FRK | ADAMTSL3 | ENSP00000476145 | ENSP00000286744 | Tyrosine-protein kinase FRK; Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. | ADAMTS-like protein 3; ADAMTS like 3. | 0.792 |