node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP10D | TMEM268 | ENSP00000273859 | ENSP00000363161 | Probable phospholipid-transporting ATPase VD; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. | Transmembrane protein 268. | 0.410 |
C1orf112 | SPAG5 | ENSP00000286031 | ENSP00000323300 | Uncharacterized protein C1orf112; Chromosome 1 open reading frame 112. | Sperm-associated antigen 5; Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule- kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. Involved in centriole duplication. Required for C [...] | 0.471 |
C1orf112 | TMEM268 | ENSP00000286031 | ENSP00000363161 | Uncharacterized protein C1orf112; Chromosome 1 open reading frame 112. | Transmembrane protein 268. | 0.465 |
CEP170B | TMEM268 | ENSP00000404151 | ENSP00000363161 | Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization. | Transmembrane protein 268. | 0.400 |
GTPBP2 | TMEM268 | ENSP00000303997 | ENSP00000363161 | GTP binding protein 2. | Transmembrane protein 268. | 0.460 |
KCNE4 | TMEM268 | ENSP00000281830 | ENSP00000363161 | Potassium voltage-gated channel subfamily E member 4; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current; Belongs to the potassium channel KCNE family. | Transmembrane protein 268. | 0.400 |
SH3RF1 | TMEM268 | ENSP00000284637 | ENSP00000363161 | E3 ubiquitin-protein ligase SH3RF1; Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin- independent endocytosis. Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pa [...] | Transmembrane protein 268. | 0.422 |
SLC35F4 | TMEM266 | ENSP00000452086 | ENSP00000373594 | Solute carrier family 35 member F4; Putative solute transporter. | Transmembrane protein 266; Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum. Despite the presence of a voltage- sensor segment, does not form a functional ion channel and its precise role remains unclear. Undergoes both rapid and slow structural rearrangements in response to changes in voltage. Contains a zinc-binding site that can regulate the slow conformational transition. | 0.596 |
SLC35F4 | TMEM268 | ENSP00000452086 | ENSP00000363161 | Solute carrier family 35 member F4; Putative solute transporter. | Transmembrane protein 268. | 0.614 |
SPAG5 | C1orf112 | ENSP00000323300 | ENSP00000286031 | Sperm-associated antigen 5; Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule- kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. Involved in centriole duplication. Required for C [...] | Uncharacterized protein C1orf112; Chromosome 1 open reading frame 112. | 0.471 |
SPAG5 | TMEM268 | ENSP00000323300 | ENSP00000363161 | Sperm-associated antigen 5; Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule- kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. Involved in centriole duplication. Required for C [...] | Transmembrane protein 268. | 0.426 |
TMEM266 | SLC35F4 | ENSP00000373594 | ENSP00000452086 | Transmembrane protein 266; Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum. Despite the presence of a voltage- sensor segment, does not form a functional ion channel and its precise role remains unclear. Undergoes both rapid and slow structural rearrangements in response to changes in voltage. Contains a zinc-binding site that can regulate the slow conformational transition. | Solute carrier family 35 member F4; Putative solute transporter. | 0.596 |
TMEM266 | TMEM268 | ENSP00000373594 | ENSP00000363161 | Transmembrane protein 266; Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum. Despite the presence of a voltage- sensor segment, does not form a functional ion channel and its precise role remains unclear. Undergoes both rapid and slow structural rearrangements in response to changes in voltage. Contains a zinc-binding site that can regulate the slow conformational transition. | Transmembrane protein 268. | 0.617 |
TMEM268 | ATP10D | ENSP00000363161 | ENSP00000273859 | Transmembrane protein 268. | Probable phospholipid-transporting ATPase VD; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. | 0.410 |
TMEM268 | C1orf112 | ENSP00000363161 | ENSP00000286031 | Transmembrane protein 268. | Uncharacterized protein C1orf112; Chromosome 1 open reading frame 112. | 0.465 |
TMEM268 | CEP170B | ENSP00000363161 | ENSP00000404151 | Transmembrane protein 268. | Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization. | 0.400 |
TMEM268 | GTPBP2 | ENSP00000363161 | ENSP00000303997 | Transmembrane protein 268. | GTP binding protein 2. | 0.460 |
TMEM268 | KCNE4 | ENSP00000363161 | ENSP00000281830 | Transmembrane protein 268. | Potassium voltage-gated channel subfamily E member 4; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current; Belongs to the potassium channel KCNE family. | 0.400 |
TMEM268 | SH3RF1 | ENSP00000363161 | ENSP00000284637 | Transmembrane protein 268. | E3 ubiquitin-protein ligase SH3RF1; Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin- independent endocytosis. Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pa [...] | 0.422 |
TMEM268 | SLC35F4 | ENSP00000363161 | ENSP00000452086 | Transmembrane protein 268. | Solute carrier family 35 member F4; Putative solute transporter. | 0.614 |