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WDR66 protein (human) - STRING interaction network
"WDR66" - Cilia- and flagella-associated protein 251 in Homo sapiens
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Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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WDR66Cilia- and flagella-associated protein 251; May regulate cilium motility through its role in the assembly of the axonemal radial spokes; WD repeat domain containing (1149 aa)    
Predicted Functional Partners:
CFAP61
Cilia- and flagella-associated protein 61; May regulate cilium motility through its role in the assembly of the axonemal radial spokes; Cilia and flagella associated (1237 aa)
     
   
  0.893
MAATS1
Cilia- and flagella-associated protein 91; May regulate cilium motility through its role in the assembly of the axonemal radial spokes (767 aa)
     
   
  0.891
RSPH3
Radial spoke head protein 3 homolog; Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia; Belongs to the flagellar radial spoke RSP3 family (560 aa)
     
   
  0.791
TBPL2
TATA box-binding protein-like protein 2; Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity); Belongs to the TBP family (375 aa)
           
  0.755
DNAH6
Dynein heavy chain 6, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity); Belongs to the dynein heavy chain family (4158 aa)
     
   
  0.749
DNAH3
Dynein heavy chain 3, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Belongs to the dynein heavy chain family (4116 aa)
     
   
  0.728
DNALI1
Axonemal dynein light intermediate polypeptide 1; May play a dynamic role in flagellar motility; Belongs to the inner dynein arm light chain family (280 aa)
     
   
  0.717
TMCC2
Transmembrane and coiled-coil domains protein 2; May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE; Transmembrane and coiled-coil domain containing (709 aa)
           
  0.649
AKAP10
A-kinase anchor protein 10, mitochondrial; Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain [...] (662 aa)
           
  0.623
CCDC40
Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39; Belongs to the CCDC40 family (1142 aa)
     
   
  0.615
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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