node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC42 | NCF2 | ENSP00000497733 | ENSP00000356505 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | Neutrophil cytosol factor 2; NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). | 0.870 |
CDC42 | PRAC1 | ENSP00000497733 | ENSP00000290294 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | PRAC1 small nuclear protein. | 0.430 |
FAM78A | PRAC1 | ENSP00000361345 | ENSP00000290294 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family. | PRAC1 small nuclear protein. | 0.432 |
FAM78A | ZNF540 | ENSP00000361345 | ENSP00000324598 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family. | Zinc finger protein 540; May act as a transcriptional repressor. | 0.572 |
HOXB13 | PRAC1 | ENSP00000290295 | ENSP00000290294 | Homeobox protein Hox-B13; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA. Belongs to the Abd-B homeobox family. | PRAC1 small nuclear protein. | 0.988 |
HOXB13 | PRAC2 | ENSP00000290295 | ENSP00000484945 | Homeobox protein Hox-B13; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA. Belongs to the Abd-B homeobox family. | PRAC2 small nuclear protein. | 0.921 |
NCF2 | CDC42 | ENSP00000356505 | ENSP00000497733 | Neutrophil cytosol factor 2; NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | 0.870 |
NCF2 | PRAC1 | ENSP00000356505 | ENSP00000290294 | Neutrophil cytosol factor 2; NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). | PRAC1 small nuclear protein. | 0.424 |
PRAC1 | CDC42 | ENSP00000290294 | ENSP00000497733 | PRAC1 small nuclear protein. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | 0.430 |
PRAC1 | FAM78A | ENSP00000290294 | ENSP00000361345 | PRAC1 small nuclear protein. | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family. | 0.432 |
PRAC1 | HOXB13 | ENSP00000290294 | ENSP00000290295 | PRAC1 small nuclear protein. | Homeobox protein Hox-B13; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA. Belongs to the Abd-B homeobox family. | 0.988 |
PRAC1 | NCF2 | ENSP00000290294 | ENSP00000356505 | PRAC1 small nuclear protein. | Neutrophil cytosol factor 2; NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). | 0.424 |
PRAC1 | PRAC2 | ENSP00000290294 | ENSP00000484945 | PRAC1 small nuclear protein. | PRAC2 small nuclear protein. | 0.990 |
PRAC1 | ZNF540 | ENSP00000290294 | ENSP00000324598 | PRAC1 small nuclear protein. | Zinc finger protein 540; May act as a transcriptional repressor. | 0.449 |
PRAC2 | HOXB13 | ENSP00000484945 | ENSP00000290295 | PRAC2 small nuclear protein. | Homeobox protein Hox-B13; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA. Belongs to the Abd-B homeobox family. | 0.921 |
PRAC2 | PRAC1 | ENSP00000484945 | ENSP00000290294 | PRAC2 small nuclear protein. | PRAC1 small nuclear protein. | 0.990 |
ZNF540 | FAM78A | ENSP00000324598 | ENSP00000361345 | Zinc finger protein 540; May act as a transcriptional repressor. | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family. | 0.572 |
ZNF540 | PRAC1 | ENSP00000324598 | ENSP00000290294 | Zinc finger protein 540; May act as a transcriptional repressor. | PRAC1 small nuclear protein. | 0.449 |