STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCDC142Coiled-coil domain containing 142. (743 aa)    
Predicted Functional Partners:
TTC31
Tetratricopeptide repeat domain 31.
   
  
 0.678
C2orf81
Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81.
   
  
 0.601
WDR54
WD repeat-containing protein 54; When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation.
      
 0.555
DQX1
ATP-dependent RNA helicase DQX1; DEAQ-box RNA dependent ATPase 1.
   
  
 0.503
INO80B
INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle.
   
  
 0.475
MRPL53
Mitochondrial ribosomal protein L53.
      
 0.474
CCDC192
Coiled-coil domain containing 192.
      
 0.474
M1AP
Meiosis 1 arrest protein; Required for meiosis I progression during spermatogenesis.
      
 0.459
LBX2
Transcription factor LBX2; Putative transcription factor.
      
 0.435
DDX39A
ATP-dependent RNA helicase DDX39A; [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus; Belongs to the DEAD box helicase family. DECD subfamily.
   
 
 0.431
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.