| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C22orf15 | DRICH1 | ENSP00000305096 | ENSP00000316137 | Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15. | Aspartate-rich protein 1; Aspartate rich 1. | 0.604 |
| C22orf15 | LRRC75B | ENSP00000305096 | ENSP00000320520 | Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15. | Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B. | 0.718 |
| C22orf15 | RGL4 | ENSP00000305096 | ENSP00000290691 | Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15. | Ral-GDS-related protein; Ral guanine nucleotide dissociation stimulator like 4. | 0.481 |
| C22orf15 | ZNF70 | ENSP00000305096 | ENSP00000339314 | Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15. | Zinc finger protein 70; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.533 |
| DRICH1 | C22orf15 | ENSP00000316137 | ENSP00000305096 | Aspartate-rich protein 1; Aspartate rich 1. | Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15. | 0.604 |
| DRICH1 | LRRC75B | ENSP00000316137 | ENSP00000320520 | Aspartate-rich protein 1; Aspartate rich 1. | Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B. | 0.622 |
| DRICH1 | RGL4 | ENSP00000316137 | ENSP00000290691 | Aspartate-rich protein 1; Aspartate rich 1. | Ral-GDS-related protein; Ral guanine nucleotide dissociation stimulator like 4. | 0.554 |
| DRICH1 | ZNF70 | ENSP00000316137 | ENSP00000339314 | Aspartate-rich protein 1; Aspartate rich 1. | Zinc finger protein 70; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.589 |
| HRAS | RALA | ENSP00000407586 | ENSP00000005257 | GTPase HRas, N-terminally processed; Involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. | Ras-related protein Ral-A; Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin- dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of t [...] | 0.831 |
| HRAS | RALB | ENSP00000407586 | ENSP00000272519 | GTPase HRas, N-terminally processed; Involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. | Ras-related protein Ral-B; Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis. In l [...] | 0.586 |
| HRAS | RAP1A | ENSP00000407586 | ENSP00000358723 | GTPase HRas, N-terminally processed; Involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. | Ras-related protein Rap-1A; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)- induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial gro [...] | 0.703 |
| HRAS | RGL4 | ENSP00000407586 | ENSP00000290691 | GTPase HRas, N-terminally processed; Involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. | Ral-GDS-related protein; Ral guanine nucleotide dissociation stimulator like 4. | 0.766 |
| LRRC75B | C22orf15 | ENSP00000320520 | ENSP00000305096 | Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B. | Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15. | 0.718 |
| LRRC75B | DRICH1 | ENSP00000320520 | ENSP00000316137 | Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B. | Aspartate-rich protein 1; Aspartate rich 1. | 0.622 |
| LRRC75B | RGL4 | ENSP00000320520 | ENSP00000290691 | Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B. | Ral-GDS-related protein; Ral guanine nucleotide dissociation stimulator like 4. | 0.507 |
| LRRC75B | ZNF70 | ENSP00000320520 | ENSP00000339314 | Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B. | Zinc finger protein 70; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.571 |
| OCIAD1 | RGL4 | ENSP00000370882 | ENSP00000290691 | OCIA domain-containing protein 1; Maintains stem cell potency (By similarity). Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity). May act as a scaffold, increasing STAT3 recruitment onto endosomes (By similarity). Involved in integrin-mediated cancer cell adhesion and colony formation in ovarian cancer. Belongs to the OCIAD1 family. | Ral-GDS-related protein; Ral guanine nucleotide dissociation stimulator like 4. | 0.523 |
| RALA | HRAS | ENSP00000005257 | ENSP00000407586 | Ras-related protein Ral-A; Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin- dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of t [...] | GTPase HRas, N-terminally processed; Involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. | 0.831 |
| RALA | RALB | ENSP00000005257 | ENSP00000272519 | Ras-related protein Ral-A; Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin- dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of t [...] | Ras-related protein Ral-B; Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis. In l [...] | 0.938 |
| RALA | RAP1A | ENSP00000005257 | ENSP00000358723 | Ras-related protein Ral-A; Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin- dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of t [...] | Ras-related protein Rap-1A; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)- induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial gro [...] | 0.445 |