node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CRNN | IVL | ENSP00000271835 | ENSP00000357753 | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | 0.478 |
CRNN | KRT78 | ENSP00000271835 | ENSP00000306261 | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | Keratin, type II cytoskeletal 78; Keratin 78; Belongs to the intermediate filament family. | 0.758 |
CRNN | LOR | ENSP00000271835 | ENSP00000357731 | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | Loricrin; Major keratinocyte cell envelope protein. | 0.557 |
CRNN | PGLYRP3 | ENSP00000271835 | ENSP00000290722 | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | Peptidoglycan recognition protein 3; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. | 0.482 |
DHTKD1 | PGLYRP3 | ENSP00000263035 | ENSP00000290722 | Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial; The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). | Peptidoglycan recognition protein 3; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. | 0.596 |
IVL | CRNN | ENSP00000357753 | ENSP00000271835 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | 0.478 |
IVL | LCE1A | ENSP00000357753 | ENSP00000334869 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | Late cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum. | 0.856 |
IVL | LCE3B | ENSP00000357753 | ENSP00000335358 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | Late cornified envelope protein 3B; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens. | 0.843 |
IVL | LCE3C | ENSP00000357753 | ENSP00000334644 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | Late cornified envelope protein 3C; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens. | 0.828 |
IVL | LOR | ENSP00000357753 | ENSP00000357731 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | Loricrin; Major keratinocyte cell envelope protein. | 0.999 |
IVL | PGLYRP3 | ENSP00000357753 | ENSP00000290722 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | Peptidoglycan recognition protein 3; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. | 0.593 |
IVL | PGLYRP4 | ENSP00000357753 | ENSP00000352672 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | Peptidoglycan recognition protein 4; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity. | 0.633 |
KRT78 | CRNN | ENSP00000306261 | ENSP00000271835 | Keratin, type II cytoskeletal 78; Keratin 78; Belongs to the intermediate filament family. | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | 0.758 |
KRT78 | PGLYRP3 | ENSP00000306261 | ENSP00000290722 | Keratin, type II cytoskeletal 78; Keratin 78; Belongs to the intermediate filament family. | Peptidoglycan recognition protein 3; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. | 0.463 |
LCE1A | IVL | ENSP00000334869 | ENSP00000357753 | Late cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum. | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | 0.856 |
LCE1A | LCE3B | ENSP00000334869 | ENSP00000335358 | Late cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum. | Late cornified envelope protein 3B; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens. | 0.936 |
LCE1A | LCE3C | ENSP00000334869 | ENSP00000334644 | Late cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum. | Late cornified envelope protein 3C; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens. | 0.946 |
LCE1A | LOR | ENSP00000334869 | ENSP00000357731 | Late cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum. | Loricrin; Major keratinocyte cell envelope protein. | 0.865 |
LCE1A | PGLYRP3 | ENSP00000334869 | ENSP00000290722 | Late cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum. | Peptidoglycan recognition protein 3; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. | 0.738 |
LCE1A | PGLYRP4 | ENSP00000334869 | ENSP00000352672 | Late cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum. | Peptidoglycan recognition protein 4; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity. | 0.726 |