C21orf58 protein (human) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	C21orf58	ENSP00000220592	ENSP00000291691	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Uncharacterized protein C21orf58; Chromosome 21 open reading frame 58.	0.475
C21orf58	AGO2	ENSP00000291691	ENSP00000220592	Uncharacterized protein C21orf58; Chromosome 21 open reading frame 58.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.475
C21orf58	CDC123	ENSP00000291691	ENSP00000281141	Uncharacterized protein C21orf58; Chromosome 21 open reading frame 58.	Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle.	0.457
C21orf58	NEK4	ENSP00000291691	ENSP00000233027	Uncharacterized protein C21orf58; Chromosome 21 open reading frame 58.	Serine/threonine-protein kinase Nek4; Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.	0.470
C21orf58	SCAF4	ENSP00000291691	ENSP00000286835	Uncharacterized protein C21orf58; Chromosome 21 open reading frame 58.	SR-related and CTD-associated factor 4; Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently [...]	0.509
C21orf58	SPATC1L	ENSP00000291691	ENSP00000291672	Uncharacterized protein C21orf58; Chromosome 21 open reading frame 58.	Speriolin-like protein; Spermatogenesis and centriole associated 1 like.	0.436
C21orf58	YBEY	ENSP00000291691	ENSP00000329614	Uncharacterized protein C21orf58; Chromosome 21 open reading frame 58.	Endoribonuclease YbeY; Single strand-specific metallo-endoribonuclease involved in rRNA maturation.	0.505
C21orf58	ZNF526	ENSP00000291691	ENSP00000301215	Uncharacterized protein C21orf58; Chromosome 21 open reading frame 58.	Zinc finger protein 526; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.	0.485
CDC123	C21orf58	ENSP00000281141	ENSP00000291691	Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle.	Uncharacterized protein C21orf58; Chromosome 21 open reading frame 58.	0.457
CDC123	YBEY	ENSP00000281141	ENSP00000329614	Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle.	Endoribonuclease YbeY; Single strand-specific metallo-endoribonuclease involved in rRNA maturation.	0.457
NEK4	C21orf58	ENSP00000233027	ENSP00000291691	Serine/threonine-protein kinase Nek4; Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.	Uncharacterized protein C21orf58; Chromosome 21 open reading frame 58.	0.470
SCAF4	C21orf58	ENSP00000286835	ENSP00000291691	SR-related and CTD-associated factor 4; Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently [...]	Uncharacterized protein C21orf58; Chromosome 21 open reading frame 58.	0.509
SPATC1L	C21orf58	ENSP00000291672	ENSP00000291691	Speriolin-like protein; Spermatogenesis and centriole associated 1 like.	Uncharacterized protein C21orf58; Chromosome 21 open reading frame 58.	0.436
SPATC1L	YBEY	ENSP00000291672	ENSP00000329614	Speriolin-like protein; Spermatogenesis and centriole associated 1 like.	Endoribonuclease YbeY; Single strand-specific metallo-endoribonuclease involved in rRNA maturation.	0.405
YBEY	C21orf58	ENSP00000329614	ENSP00000291691	Endoribonuclease YbeY; Single strand-specific metallo-endoribonuclease involved in rRNA maturation.	Uncharacterized protein C21orf58; Chromosome 21 open reading frame 58.	0.505
YBEY	CDC123	ENSP00000329614	ENSP00000281141	Endoribonuclease YbeY; Single strand-specific metallo-endoribonuclease involved in rRNA maturation.	Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle.	0.457
YBEY	SPATC1L	ENSP00000329614	ENSP00000291672	Endoribonuclease YbeY; Single strand-specific metallo-endoribonuclease involved in rRNA maturation.	Speriolin-like protein; Spermatogenesis and centriole associated 1 like.	0.405
ZNF526	C21orf58	ENSP00000301215	ENSP00000291691	Zinc finger protein 526; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.	Uncharacterized protein C21orf58; Chromosome 21 open reading frame 58.	0.485