TMEM190 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C20orf85	TMEM190	ENSP00000360210	ENSP00000291934	Uncharacterized protein C20orf85; Chromosome 20 open reading frame 85.	Transmembrane protein 190.	0.791
CD69	TMEM190	ENSP00000228434	ENSP00000291934	Early activation antigen CD69; Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.	Transmembrane protein 190.	0.646
FSCB	TMEM190	ENSP00000344579	ENSP00000291934	Fibrous sheath CABYR-binding protein; May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium.	Transmembrane protein 190.	0.532
IZUMO4	LYZL4	ENSP00000378712	ENSP00000287748	Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family.	Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family.	0.456
IZUMO4	SPACA1	ENSP00000378712	ENSP00000237201	Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family.	Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis (By similarity). Important for male fertility.	0.677
IZUMO4	SPACA3	ENSP00000378712	ENSP00000269053	Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family.	Sperm acrosome membrane-associated protein 3, processed form; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N- acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.	0.533
IZUMO4	SPEM1	ENSP00000378712	ENSP00000315554	Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family.	Spermatid maturation protein 1; Required for proper cytoplasm removal during spermatogenesis.	0.413
IZUMO4	TMEM190	ENSP00000378712	ENSP00000291934	Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family.	Transmembrane protein 190.	0.582
IZUMO4	ZPBP	ENSP00000378712	ENSP00000046087	Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family.	Zona pellucida-binding protein 1; Plays a role in acrosome compaction and sperm morphogenesis. Is implicated in sperm-oocyte interaction during fertilization (By similarity).	0.885
LDLRAD1	TMEM190	ENSP00000360411	ENSP00000291934	Low density lipoprotein receptor class A domain containing 1.	Transmembrane protein 190.	0.649
LYZL4	IZUMO4	ENSP00000287748	ENSP00000378712	Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family.	Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family.	0.456
LYZL4	SPACA1	ENSP00000287748	ENSP00000237201	Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family.	Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis (By similarity). Important for male fertility.	0.642
LYZL4	SPACA3	ENSP00000287748	ENSP00000269053	Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family.	Sperm acrosome membrane-associated protein 3, processed form; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N- acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.	0.765
LYZL4	TMEM190	ENSP00000287748	ENSP00000291934	Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family.	Transmembrane protein 190.	0.642
LYZL4	ZPBP	ENSP00000287748	ENSP00000046087	Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family.	Zona pellucida-binding protein 1; Plays a role in acrosome compaction and sperm morphogenesis. Is implicated in sperm-oocyte interaction during fertilization (By similarity).	0.767
SPACA1	IZUMO4	ENSP00000237201	ENSP00000378712	Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis (By similarity). Important for male fertility.	Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family.	0.677
SPACA1	LYZL4	ENSP00000237201	ENSP00000287748	Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis (By similarity). Important for male fertility.	Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family.	0.642
SPACA1	SPACA3	ENSP00000237201	ENSP00000269053	Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis (By similarity). Important for male fertility.	Sperm acrosome membrane-associated protein 3, processed form; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N- acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.	0.650
SPACA1	SPEM1	ENSP00000237201	ENSP00000315554	Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis (By similarity). Important for male fertility.	Spermatid maturation protein 1; Required for proper cytoplasm removal during spermatogenesis.	0.533
SPACA1	TMEM190	ENSP00000237201	ENSP00000291934	Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis (By similarity). Important for male fertility.	Transmembrane protein 190.	0.597