Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALPP | NLRP8 | ENSP00000375881 | ENSP00000291971 | Alkaline phosphatase, placental. | NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation. | 0.408 |
| ALPP | RAX2 | ENSP00000375881 | ENSP00000450456 | Alkaline phosphatase, placental. | Retina and anterior neural fold homeobox protein 2; May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter. | 0.435 |
| ALPP | USP49 | ENSP00000375881 | ENSP00000377797 | Alkaline phosphatase, placental. | Ubiquitin carboxyl-terminal hydrolase 49; Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons; Belongs to the peptidase C19 family. | 0.772 |
| CASP1 | MEFV | ENSP00000433138 | ENSP00000219596 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] | Pyrin; Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation. However, it [...] | 0.999 |
| CASP1 | NLRP8 | ENSP00000433138 | ENSP00000291971 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] | NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation. | 0.585 |
| DNAJB4 | DNAJB5 | ENSP00000359799 | ENSP00000404079 | DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | DnaJ heat shock protein family member B5. | 0.876 |
| DNAJB4 | NLRP8 | ENSP00000359799 | ENSP00000291971 | DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation. | 0.584 |
| DNAJB5 | DNAJB4 | ENSP00000404079 | ENSP00000359799 | DnaJ heat shock protein family member B5. | DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | 0.876 |
| DNAJB5 | NLRP8 | ENSP00000404079 | ENSP00000291971 | DnaJ heat shock protein family member B5. | NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation. | 0.567 |
| MEFV | CASP1 | ENSP00000219596 | ENSP00000433138 | Pyrin; Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation. However, it [...] | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] | 0.999 |
| MEFV | NLRP8 | ENSP00000219596 | ENSP00000291971 | Pyrin; Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation. However, it [...] | NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation. | 0.823 |
| NLRP8 | ALPP | ENSP00000291971 | ENSP00000375881 | NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation. | Alkaline phosphatase, placental. | 0.408 |
| NLRP8 | CASP1 | ENSP00000291971 | ENSP00000433138 | NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation. | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] | 0.585 |
| NLRP8 | DNAJB4 | ENSP00000291971 | ENSP00000359799 | NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation. | DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | 0.584 |
| NLRP8 | DNAJB5 | ENSP00000291971 | ENSP00000404079 | NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation. | DnaJ heat shock protein family member B5. | 0.567 |
| NLRP8 | MEFV | ENSP00000291971 | ENSP00000219596 | NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation. | Pyrin; Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation. However, it [...] | 0.823 |
| NLRP8 | OR10P1 | ENSP00000291971 | ENSP00000308082 | NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation. | Olfactory receptor 10P1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.460 |
| NLRP8 | RAX2 | ENSP00000291971 | ENSP00000450456 | NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation. | Retina and anterior neural fold homeobox protein 2; May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter. | 0.404 |
| NLRP8 | USP49 | ENSP00000291971 | ENSP00000377797 | NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation. | Ubiquitin carboxyl-terminal hydrolase 49; Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons; Belongs to the peptidase C19 family. | 0.416 |
| OR10P1 | NLRP8 | ENSP00000308082 | ENSP00000291971 | Olfactory receptor 10P1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation. | 0.460 |
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