node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CEPT1 | MED15 | ENSP00000441980 | ENSP00000263205 | Choline/ethanolaminephosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity. | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol [...] | 0.417 |
CEPT1 | TLCD1 | ENSP00000441980 | ENSP00000292090 | Choline/ethanolaminephosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity. | TLC domain-containing protein 1; Regulates the composition and fluidity of the plasma membrane. Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity. Does not appear to have any effect on LCPUFA synthesis. | 0.502 |
DHRS12 | TLCD1 | ENSP00000411565 | ENSP00000292090 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | TLC domain-containing protein 1; Regulates the composition and fluidity of the plasma membrane. Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity. Does not appear to have any effect on LCPUFA synthesis. | 0.498 |
DHRS7B | TLCD1 | ENSP00000378887 | ENSP00000292090 | Dehydrogenase/reductase SDR family member 7B; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | TLC domain-containing protein 1; Regulates the composition and fluidity of the plasma membrane. Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity. Does not appear to have any effect on LCPUFA synthesis. | 0.581 |
EFCAB8 | MTRNR2L3 | ENSP00000383366 | ENSP00000443339 | EF-hand calcium-binding domain-containing protein 8; EF-hand calcium binding domain 8. | Humanin-like 3; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family. | 0.468 |
EFCAB8 | POP1 | ENSP00000383366 | ENSP00000385787 | EF-hand calcium-binding domain-containing protein 8; EF-hand calcium binding domain 8. | Ribonucleases P/MRP protein subunit POP1; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. | 0.463 |
EFCAB8 | TLCD1 | ENSP00000383366 | ENSP00000292090 | EF-hand calcium-binding domain-containing protein 8; EF-hand calcium binding domain 8. | TLC domain-containing protein 1; Regulates the composition and fluidity of the plasma membrane. Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity. Does not appear to have any effect on LCPUFA synthesis. | 0.427 |
MED15 | CEPT1 | ENSP00000263205 | ENSP00000441980 | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol [...] | Choline/ethanolaminephosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity. | 0.417 |
MED15 | TLCD1 | ENSP00000263205 | ENSP00000292090 | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol [...] | TLC domain-containing protein 1; Regulates the composition and fluidity of the plasma membrane. Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity. Does not appear to have any effect on LCPUFA synthesis. | 0.521 |
MTRNR2L3 | EFCAB8 | ENSP00000443339 | ENSP00000383366 | Humanin-like 3; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family. | EF-hand calcium-binding domain-containing protein 8; EF-hand calcium binding domain 8. | 0.468 |
MTRNR2L3 | POP1 | ENSP00000443339 | ENSP00000385787 | Humanin-like 3; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family. | Ribonucleases P/MRP protein subunit POP1; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. | 0.479 |
MTRNR2L3 | TLCD1 | ENSP00000443339 | ENSP00000292090 | Humanin-like 3; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family. | TLC domain-containing protein 1; Regulates the composition and fluidity of the plasma membrane. Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity. Does not appear to have any effect on LCPUFA synthesis. | 0.445 |
OCEL1 | SMIM29 | ENSP00000215061 | ENSP00000489784 | occludin/ELL domain containing 1; Belongs to the ELL/occludin family. | Small integral membrane protein 29. | 0.401 |
OCEL1 | TLCD1 | ENSP00000215061 | ENSP00000292090 | occludin/ELL domain containing 1; Belongs to the ELL/occludin family. | TLC domain-containing protein 1; Regulates the composition and fluidity of the plasma membrane. Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity. Does not appear to have any effect on LCPUFA synthesis. | 0.436 |
POP1 | EFCAB8 | ENSP00000385787 | ENSP00000383366 | Ribonucleases P/MRP protein subunit POP1; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. | EF-hand calcium-binding domain-containing protein 8; EF-hand calcium binding domain 8. | 0.463 |
POP1 | MTRNR2L3 | ENSP00000385787 | ENSP00000443339 | Ribonucleases P/MRP protein subunit POP1; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. | Humanin-like 3; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family. | 0.479 |
POP1 | TLCD1 | ENSP00000385787 | ENSP00000292090 | Ribonucleases P/MRP protein subunit POP1; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. | TLC domain-containing protein 1; Regulates the composition and fluidity of the plasma membrane. Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity. Does not appear to have any effect on LCPUFA synthesis. | 0.493 |
SMIM29 | OCEL1 | ENSP00000489784 | ENSP00000215061 | Small integral membrane protein 29. | occludin/ELL domain containing 1; Belongs to the ELL/occludin family. | 0.401 |
SMIM29 | TLCD1 | ENSP00000489784 | ENSP00000292090 | Small integral membrane protein 29. | TLC domain-containing protein 1; Regulates the composition and fluidity of the plasma membrane. Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity. Does not appear to have any effect on LCPUFA synthesis. | 0.423 |
TLCD1 | CEPT1 | ENSP00000292090 | ENSP00000441980 | TLC domain-containing protein 1; Regulates the composition and fluidity of the plasma membrane. Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity. Does not appear to have any effect on LCPUFA synthesis. | Choline/ethanolaminephosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity. | 0.502 |