STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF251Zinc finger protein 251; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (671 aa)    
Predicted Functional Partners:
PNMA5
Paraneoplastic antigen-like protein 5; PNMA family member 5; Belongs to the PNMA family.
    
 0.589
WFDC12
WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor.
      
 0.564
CCDC57
Coiled-coil domain containing 57.
   
 
 0.528
MORN1
MORN repeat containing 1.
    
 
 0.503
MEGF6
Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6.
   
 
 0.462
PNMA3
Paraneoplastic antigen Ma3; PNMA family member 3; Belongs to the PNMA family.
    
 0.443
RNF113A
E3 ubiquitin-protein ligase RNF113A; Required for pre-mRNA splicing as component of the spliceosome. E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents. Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling.
   
 
 0.440
ZDHHC9
Palmitoyltransferase ZDHHC9; The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.
   
 
 0.430
ZDBF2
DBF4-type zinc finger-containing protein 2; Zinc finger DBF-type containing 2.
   
  
 0.414
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.