FAM171A2 protein (human) - STRING interaction network

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Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALG1L	FAM171A2	ENSP00000482705	ENSP00000293443	Putative glycosyltransferase ALG1-like; Putative glycosyltransferase.	Protein FAM171A2; Family with sequence similarity 171 member A2.	0.553
BTN2A1	FAM171A2	ENSP00000312158	ENSP00000293443	Butyrophilin subfamily 2 member A1.	Protein FAM171A2; Family with sequence similarity 171 member A2.	0.527
CD53	FAM171A2	ENSP00000497382	ENSP00000293443	Leukocyte surface antigen CD53; Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).	Protein FAM171A2; Family with sequence similarity 171 member A2.	0.636
CEP170	FAM171A2	ENSP00000355500	ENSP00000293443	Centrosomal protein of 170 kDa; Plays a role in microtubule organization. Required for centriole subdistal appendage assembly. Belongs to the CEP170 family.	Protein FAM171A2; Family with sequence similarity 171 member A2.	0.467
FAM171A2	ALG1L	ENSP00000293443	ENSP00000482705	Protein FAM171A2; Family with sequence similarity 171 member A2.	Putative glycosyltransferase ALG1-like; Putative glycosyltransferase.	0.553
FAM171A2	BTN2A1	ENSP00000293443	ENSP00000312158	Protein FAM171A2; Family with sequence similarity 171 member A2.	Butyrophilin subfamily 2 member A1.	0.527
FAM171A2	CD53	ENSP00000293443	ENSP00000497382	Protein FAM171A2; Family with sequence similarity 171 member A2.	Leukocyte surface antigen CD53; Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).	0.636
FAM171A2	CEP170	ENSP00000293443	ENSP00000355500	Protein FAM171A2; Family with sequence similarity 171 member A2.	Centrosomal protein of 170 kDa; Plays a role in microtubule organization. Required for centriole subdistal appendage assembly. Belongs to the CEP170 family.	0.467
FAM171A2	LMBR1L	ENSP00000293443	ENSP00000267102	Protein FAM171A2; Family with sequence similarity 171 member A2.	Protein LMBR1L; Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta- catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis. Belongs to the LIMR family.	0.457
FAM171A2	LRFN1	ENSP00000293443	ENSP00000248668	Protein FAM171A2; Family with sequence similarity 171 member A2.	Leucine-rich repeat and fibronectin type III domain-containing protein 1; Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity).	0.416
FAM171A2	MEIOC	ENSP00000293443	ENSP00000386452	Protein FAM171A2; Family with sequence similarity 171 member A2.	Meiosis-specific coiled-coil domain-containing protein MEIOC; Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle.	0.453
FAM171A2	NTRK3	ENSP00000293443	ENSP00000354207	Protein FAM171A2; Family with sequence similarity 171 member A2.	NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.	0.524
FAM171A2	P4HA3	ENSP00000293443	ENSP00000401749	Protein FAM171A2; Family with sequence similarity 171 member A2.	Prolyl 4-hydroxylase subunit alpha-3; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family.	0.576
FAM171A2	PCDHGB1	ENSP00000293443	ENSP00000429273	Protein FAM171A2; Family with sequence similarity 171 member A2.	Protocadherin gamma-B1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	0.762
LMBR1L	FAM171A2	ENSP00000267102	ENSP00000293443	Protein LMBR1L; Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta- catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis. Belongs to the LIMR family.	Protein FAM171A2; Family with sequence similarity 171 member A2.	0.457
LRFN1	FAM171A2	ENSP00000248668	ENSP00000293443	Leucine-rich repeat and fibronectin type III domain-containing protein 1; Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity).	Protein FAM171A2; Family with sequence similarity 171 member A2.	0.416
MEIOC	FAM171A2	ENSP00000386452	ENSP00000293443	Meiosis-specific coiled-coil domain-containing protein MEIOC; Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle.	Protein FAM171A2; Family with sequence similarity 171 member A2.	0.453
NTRK3	FAM171A2	ENSP00000354207	ENSP00000293443	NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.	Protein FAM171A2; Family with sequence similarity 171 member A2.	0.524
P4HA3	FAM171A2	ENSP00000401749	ENSP00000293443	Prolyl 4-hydroxylase subunit alpha-3; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family.	Protein FAM171A2; Family with sequence similarity 171 member A2.	0.576
PCDHGB1	FAM171A2	ENSP00000429273	ENSP00000293443	Protocadherin gamma-B1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.	Protein FAM171A2; Family with sequence similarity 171 member A2.	0.762