STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRT83Keratin, type II cuticular Hb3; Keratins, type II (493 aa)    
Predicted Functional Partners:
KRT25
Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization
   
0.934
KRT38
Keratin, type I cuticular Ha8; Keratins, type I; Belongs to the intermediate filament family
   
0.929
KRT34
Keratin, type I cuticular Ha4; Keratins, type I
   
0.929
KRT32
Keratin, type I cuticular Ha2; Keratins, type I; Belongs to the intermediate filament family
   
0.927
KRT24
Keratin, type I cytoskeletal 24; Keratins, type I
   
0.927
KRT35
Keratin, type I cuticular Ha5; Keratins, type I
   
0.927
KRT14
Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro
   
0.924
KRT37
Keratin, type I cuticular Ha7; Keratins, type I; Belongs to the intermediate filament family
   
0.924
KRT16
Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance
   
0.923
KRT15
Keratin, type I cytoskeletal 15; Keratins, type I
   
0.921
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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