ENSP00000293826 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGGF1	ENSP00000293826	ENSP00000316109	ENSP00000293826	Angiogenic factor with G patch and FHA domains 1; Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.	TNFSF12-TNFSF13 readthrough; Belongs to the tumor necrosis factor family.	0.715
AGGF1	TNFRSF12A	ENSP00000316109	ENSP00000326737	Angiogenic factor with G patch and FHA domains 1; Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.	Tumor necrosis factor receptor superfamily member 12A; Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.	0.673
AGGF1	TRAF5	ENSP00000316109	ENSP00000261464	Angiogenic factor with G patch and FHA domains 1; Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.	TNF receptor-associated factor 5; Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF- kappa-B by EIF2AK2/PKR.	0.490
ARL10	ENSP00000293826	ENSP00000308496	ENSP00000293826	ADP-ribosylation factor-like protein 10; ADP ribosylation factor like GTPase 10; Belongs to the small GTPase superfamily. Arf family.	TNFSF12-TNFSF13 readthrough; Belongs to the tumor necrosis factor family.	0.563
CHCHD2	ENSP00000293826	ENSP00000378812	ENSP00000293826	Coiled-coil-helix-coiled-coil-helix domain-containing protein 2; Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen).	TNFSF12-TNFSF13 readthrough; Belongs to the tumor necrosis factor family.	0.557
ENSP00000293826	AGGF1	ENSP00000293826	ENSP00000316109	TNFSF12-TNFSF13 readthrough; Belongs to the tumor necrosis factor family.	Angiogenic factor with G patch and FHA domains 1; Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.	0.715
ENSP00000293826	ARL10	ENSP00000293826	ENSP00000308496	TNFSF12-TNFSF13 readthrough; Belongs to the tumor necrosis factor family.	ADP-ribosylation factor-like protein 10; ADP ribosylation factor like GTPase 10; Belongs to the small GTPase superfamily. Arf family.	0.563
ENSP00000293826	CHCHD2	ENSP00000293826	ENSP00000378812	TNFSF12-TNFSF13 readthrough; Belongs to the tumor necrosis factor family.	Coiled-coil-helix-coiled-coil-helix domain-containing protein 2; Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen).	0.557
ENSP00000293826	FAM3C	ENSP00000293826	ENSP00000353025	TNFSF12-TNFSF13 readthrough; Belongs to the tumor necrosis factor family.	Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.	0.553
ENSP00000293826	KLHDC3	ENSP00000293826	ENSP00000313995	TNFSF12-TNFSF13 readthrough; Belongs to the tumor necrosis factor family.	Kelch domain-containing protein 3; May be involved in meiotic recombination process.	0.553
ENSP00000293826	KPNB1	ENSP00000293826	ENSP00000290158	TNFSF12-TNFSF13 readthrough; Belongs to the tumor necrosis factor family.	Importin subunit beta-1; Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic [...]	0.553
ENSP00000293826	TNFRSF12A	ENSP00000293826	ENSP00000326737	TNFSF12-TNFSF13 readthrough; Belongs to the tumor necrosis factor family.	Tumor necrosis factor receptor superfamily member 12A; Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.	0.682
ENSP00000293826	TNFRSF13B	ENSP00000293826	ENSP00000261652	TNFSF12-TNFSF13 readthrough; Belongs to the tumor necrosis factor family.	Tumor necrosis factor receptor superfamily member 13B; Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin- dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.	0.421
ENSP00000293826	TNFSF13	ENSP00000293826	ENSP00000343505	TNFSF12-TNFSF13 readthrough; Belongs to the tumor necrosis factor family.	Tumor necrosis factor ligand superfamily member 13; Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.	0.978
ENSP00000293826	TRAF5	ENSP00000293826	ENSP00000261464	TNFSF12-TNFSF13 readthrough; Belongs to the tumor necrosis factor family.	TNF receptor-associated factor 5; Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF- kappa-B by EIF2AK2/PKR.	0.467
FAM3C	ENSP00000293826	ENSP00000353025	ENSP00000293826	Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.	TNFSF12-TNFSF13 readthrough; Belongs to the tumor necrosis factor family.	0.553
KLHDC3	ENSP00000293826	ENSP00000313995	ENSP00000293826	Kelch domain-containing protein 3; May be involved in meiotic recombination process.	TNFSF12-TNFSF13 readthrough; Belongs to the tumor necrosis factor family.	0.553
KPNB1	ENSP00000293826	ENSP00000290158	ENSP00000293826	Importin subunit beta-1; Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic [...]	TNFSF12-TNFSF13 readthrough; Belongs to the tumor necrosis factor family.	0.553
TNFRSF12A	AGGF1	ENSP00000326737	ENSP00000316109	Tumor necrosis factor receptor superfamily member 12A; Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.	Angiogenic factor with G patch and FHA domains 1; Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.	0.673
TNFRSF12A	ENSP00000293826	ENSP00000326737	ENSP00000293826	Tumor necrosis factor receptor superfamily member 12A; Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.	TNFSF12-TNFSF13 readthrough; Belongs to the tumor necrosis factor family.	0.682