node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC38 | CCDC42 | ENSP00000345470 | ENSP00000293845 | Coiled-coil domain containing 38. | Coiled-coil domain-containing protein 42; Required for sperm development. | 0.808 |
CCDC42 | CCDC38 | ENSP00000293845 | ENSP00000345470 | Coiled-coil domain-containing protein 42; Required for sperm development. | Coiled-coil domain containing 38. | 0.808 |
CCDC42 | CEP131 | ENSP00000293845 | ENSP00000269392 | Coiled-coil domain-containing protein 42; Required for sperm development. | Centrosomal protein of 131 kDa; Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner [...] | 0.560 |
CCDC42 | CFAP100 | ENSP00000293845 | ENSP00000344749 | Coiled-coil domain-containing protein 42; Required for sperm development. | Cilia- and flagella-associated protein 100; May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm. | 0.525 |
CCDC42 | CNTROB | ENSP00000293845 | ENSP00000369614 | Coiled-coil domain-containing protein 42; Required for sperm development. | Centrobin; Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. | 0.644 |
CCDC42 | IFT88 | ENSP00000293845 | ENSP00000323580 | Coiled-coil domain-containing protein 42; Required for sperm development. | Intraflagellar transport protein 88 homolog; Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. | 0.572 |
CCDC42 | OAZ3 | ENSP00000293845 | ENSP00000383784 | Coiled-coil domain-containing protein 42; Required for sperm development. | Ornithine decarboxylase antizyme 3; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER- Golgi intermediate compartment (ERGIC) to the cytos [...] | 0.593 |
CCDC42 | ODF1 | ENSP00000293845 | ENSP00000285402 | Coiled-coil domain-containing protein 42; Required for sperm development. | Outer dense fiber protein 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. | 0.773 |
CCDC42 | ODF2 | ENSP00000293845 | ENSP00000403453 | Coiled-coil domain-containing protein 42; Required for sperm development. | Outer dense fiber protein 2; Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to th [...] | 0.604 |
CCDC42 | SUN5 | ENSP00000293845 | ENSP00000348496 | Coiled-coil domain-containing protein 42; Required for sperm development. | SUN domain-containing protein 5; Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope. | 0.559 |
CCDC42 | TENT5C | ENSP00000293845 | ENSP00000358458 | Coiled-coil domain-containing protein 42; Required for sperm development. | Terminal nucleotidyltransferase 5C; Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase which enhances mRNA stability and gene expression. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein and may be involved in induction of cell death. | 0.499 |
CEP131 | CCDC42 | ENSP00000269392 | ENSP00000293845 | Centrosomal protein of 131 kDa; Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner [...] | Coiled-coil domain-containing protein 42; Required for sperm development. | 0.560 |
CEP131 | CNTROB | ENSP00000269392 | ENSP00000369614 | Centrosomal protein of 131 kDa; Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner [...] | Centrobin; Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. | 0.742 |
CEP131 | IFT88 | ENSP00000269392 | ENSP00000323580 | Centrosomal protein of 131 kDa; Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner [...] | Intraflagellar transport protein 88 homolog; Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. | 0.661 |
CEP131 | OAZ3 | ENSP00000269392 | ENSP00000383784 | Centrosomal protein of 131 kDa; Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner [...] | Ornithine decarboxylase antizyme 3; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER- Golgi intermediate compartment (ERGIC) to the cytos [...] | 0.502 |
CEP131 | TENT5C | ENSP00000269392 | ENSP00000358458 | Centrosomal protein of 131 kDa; Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner [...] | Terminal nucleotidyltransferase 5C; Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase which enhances mRNA stability and gene expression. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein and may be involved in induction of cell death. | 0.428 |
CFAP100 | CCDC42 | ENSP00000344749 | ENSP00000293845 | Cilia- and flagella-associated protein 100; May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm. | Coiled-coil domain-containing protein 42; Required for sperm development. | 0.525 |
CNTROB | CCDC42 | ENSP00000369614 | ENSP00000293845 | Centrobin; Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. | Coiled-coil domain-containing protein 42; Required for sperm development. | 0.644 |
CNTROB | CEP131 | ENSP00000369614 | ENSP00000269392 | Centrobin; Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. | Centrosomal protein of 131 kDa; Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner [...] | 0.742 |
CNTROB | IFT88 | ENSP00000369614 | ENSP00000323580 | Centrobin; Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. | Intraflagellar transport protein 88 homolog; Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. | 0.624 |