STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CZIBCXXC motif containing zinc binding protein; Belongs to the UPF0587 family. (160 aa)    
Predicted Functional Partners:
GTPBP6
GTP binding protein 6.
 
 
    0.728
CCS
Copper chaperone for superoxide dismutase; Delivers copper to copper zinc superoxide dismutase (SOD1); In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.
   
 
 0.667
RPS13
Ribosomal protein S13.
   
  
 0.467
RPS15
Ribosomal protein S15.
   
  
 0.454
KIAA0355
Uncharacterized protein KIAA0355.
      
 0.447
RCCD1
RCC1 domain-containing protein 1; Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8.
      
 0.446
DNAJC17
DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription.
   
   0.441
RSAD1
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity (Probable). Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine (By similarity); Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
   
  
 0.435
UBLCP1
Ubiquitin-like domain-containing CTD phosphatase 1; Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.
   
  
 0.434
LRATD1
Protein LRATD1; May play a role in cell morphology and motility. Belongs to the LRATD family.
      
 0.425
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.