TMCO4 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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co-expression

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gene co-occurrence

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Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP1S3	TMCO4	ENSP00000379891	ENSP00000294543	AP-1 complex subunit sigma-3; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking.	Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family.	0.553
C2CD2	TMCO4	ENSP00000369853	ENSP00000294543	C2 calcium dependent domain containing 2.	Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family.	0.546
CDK5RAP1	TMCO4	ENSP00000217372	ENSP00000294543	CDK5 regulatory subunit-associated protein 1; Specifically inhibits CDK5 activation by CDK5R1; Belongs to the methylthiotransferase family. MiaB subfamily.	Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family.	0.698
ETDB	TMCO4	ENSP00000490943	ENSP00000294543	Embryonic testis differentiation homolog B.	Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family.	0.539
FAM187B	TMCO4	ENSP00000323355	ENSP00000294543	Protein FAM187B; Family with sequence similarity 187 member B.	Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family.	0.539
FARSB	TMCO4	ENSP00000281828	ENSP00000294543	phenylalanyl-tRNA synthetase subunit beta; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.	Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family.	0.558
FLT1	TMCO4	ENSP00000282397	ENSP00000294543	Vascular endothelial growth factor receptor 1; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferati [...]	Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family.	0.587
KPTN	TMCO4	ENSP00000337850	ENSP00000294543	KICSTOR complex protein kaptin; As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.	Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family.	0.754
RAB18	TMCO4	ENSP00000478479	ENSP00000294543	Ras-related protein Rab-18; Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration.	Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family.	0.686
TMCO4	AP1S3	ENSP00000294543	ENSP00000379891	Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family.	AP-1 complex subunit sigma-3; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking.	0.553
TMCO4	C2CD2	ENSP00000294543	ENSP00000369853	Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family.	C2 calcium dependent domain containing 2.	0.546
TMCO4	CDK5RAP1	ENSP00000294543	ENSP00000217372	Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family.	CDK5 regulatory subunit-associated protein 1; Specifically inhibits CDK5 activation by CDK5R1; Belongs to the methylthiotransferase family. MiaB subfamily.	0.698
TMCO4	ETDB	ENSP00000294543	ENSP00000490943	Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family.	Embryonic testis differentiation homolog B.	0.539
TMCO4	FAM187B	ENSP00000294543	ENSP00000323355	Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family.	Protein FAM187B; Family with sequence similarity 187 member B.	0.539
TMCO4	FARSB	ENSP00000294543	ENSP00000281828	Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family.	phenylalanyl-tRNA synthetase subunit beta; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.	0.558
TMCO4	FLT1	ENSP00000294543	ENSP00000282397	Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family.	Vascular endothelial growth factor receptor 1; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferati [...]	0.587
TMCO4	KPTN	ENSP00000294543	ENSP00000337850	Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family.	KICSTOR complex protein kaptin; As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.	0.754
TMCO4	RAB18	ENSP00000294543	ENSP00000478479	Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family.	Ras-related protein Rab-18; Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration.	0.686
TMCO4	VPS29	ENSP00000294543	ENSP00000480853	Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family.	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...]	0.594
VPS29	TMCO4	ENSP00000480853	ENSP00000294543	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...]	Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family.	0.594