STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCDC27Coiled-coil domain containing 27 (656 aa)    
Predicted Functional Partners:
C1orf174
UPF0688 protein C1orf174; Chromosome 1 open reading frame 174; Belongs to the UPF0688 family
      
 0.735
CEP104
Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip
   
  
 0.665
LRRC47
Leucine-rich repeat-containing protein 47; Leucine rich repeat containing 47
      
 0.665
ACTRT2
Actin related protein T2
   
  
 0.577
WRAP73
WD repeat-containing protein WRAP73; The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal bo [...]
      
 0.553
MEGF6
Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6
      
 0.524
RERE
Arginine-glutamic acid dipeptide repeats protein; Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death; GATA zinc finger domain containing
      
 0.509
TPRG1L
Tumor protein p63 regulated 1 like; Belongs to the TPRG1 family
      
 0.431
AJAP1
Adherens junction-associated protein 1; Plays a role in cell adhesion and cell migration
      
 0.425
DFFB
DNA fragmentation factor subunit beta; Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology
      
 0.416
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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