node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGL | AMY1B | ENSP00000294724 | ENSP00000330484 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | 0.963 |
AGL | AMY2A | ENSP00000294724 | ENSP00000481450 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Pancreatic alpha-amylase; Amylase alpha 2A. | 0.961 |
AGL | AMY2B | ENSP00000294724 | ENSP00000354610 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Amylase alpha 2B; Belongs to the glycosyl hydrolase 13 family. | 0.962 |
AGL | GBE1 | ENSP00000294724 | ENSP00000410833 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | 1,4-alpha-glucan-branching enzyme; Required for normal glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule (Probable); Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. | 0.993 |
AGL | GYG2 | ENSP00000294724 | ENSP00000370555 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Glycogenin-2; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase. Belongs to the glycosyltransferase 8 family. Glycogenin subfamily. | 0.969 |
AGL | NOP53 | ENSP00000294724 | ENSP00000246802 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Ribosome biogenesis protein NOP53; Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription. Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 acti [...] | 0.983 |
AGL | PYGB | ENSP00000294724 | ENSP00000216962 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Glycogen phosphorylase, brain form; Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | 0.999 |
AGL | PYGL | ENSP00000294724 | ENSP00000216392 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Glycogen phosphorylase, liver form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | 0.997 |
AGL | PYGM | ENSP00000294724 | ENSP00000164139 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Glycogen phosphorylase, muscle form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | 0.997 |
AGL | UGP2 | ENSP00000294724 | ENSP00000338703 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | UTP--glucose-1-phosphate uridylyltransferase; Plays a central role as a glucosyl donor in cellular metabolic pathways; Belongs to the UDPGP type 1 family. | 0.967 |
AMY1B | AGL | ENSP00000330484 | ENSP00000294724 | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | 0.963 |
AMY1B | AMY2A | ENSP00000330484 | ENSP00000481450 | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | Pancreatic alpha-amylase; Amylase alpha 2A. | 0.901 |
AMY1B | AMY2B | ENSP00000330484 | ENSP00000354610 | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | Amylase alpha 2B; Belongs to the glycosyl hydrolase 13 family. | 0.915 |
AMY1B | GBE1 | ENSP00000330484 | ENSP00000410833 | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | 1,4-alpha-glucan-branching enzyme; Required for normal glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule (Probable); Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. | 0.977 |
AMY1B | GYG2 | ENSP00000330484 | ENSP00000370555 | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | Glycogenin-2; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase. Belongs to the glycosyltransferase 8 family. Glycogenin subfamily. | 0.886 |
AMY1B | PYGB | ENSP00000330484 | ENSP00000216962 | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | Glycogen phosphorylase, brain form; Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | 0.972 |
AMY1B | PYGL | ENSP00000330484 | ENSP00000216392 | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | Glycogen phosphorylase, liver form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | 0.970 |
AMY1B | PYGM | ENSP00000330484 | ENSP00000164139 | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | Glycogen phosphorylase, muscle form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | 0.970 |
AMY2A | AGL | ENSP00000481450 | ENSP00000294724 | Pancreatic alpha-amylase; Amylase alpha 2A. | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | 0.961 |
AMY2A | AMY1B | ENSP00000481450 | ENSP00000330484 | Pancreatic alpha-amylase; Amylase alpha 2A. | Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family. | 0.901 |