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ZNF281 protein (human) - STRING interaction network
"ZNF281" - Zinc finger protein 281 in Homo sapiens
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ZNF281Zinc finger protein 281; Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs- binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G- rich box in the enhancer region of these genes (895 aa)    
Predicted Functional Partners:
NANOG
Nanog homeobox; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5’-TAAT[GT][GT]-3’ or 5 [...] (305 aa)
     
 
  0.582
POTEE
POTE ankyrin domain family member E (1075 aa)
     
 
  0.568
POTEI
POTE ankyrin domain family, member I (1075 aa)
     
 
  0.568
POTEJ
POTE ankyrin domain family, member J (1038 aa)
     
 
  0.568
POTEF
POTE ankyrin domain family, member F (1075 aa)
     
 
  0.568
UBE3C
Ubiquitin protein ligase E3C; E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either ’Lys-29’- or ’Lys-48’-linked polyubiquitin chains. Has preference for ’Lys-48’ linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo (1083 aa)
     
 
  0.544
PRPF4B
PRP4 pre-mRNA processing factor 4 homolog B (yeast); Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF (1007 aa)
     
   
  0.531
USP10
Ubiquitin specific peptidase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability- in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels- mediates deubiquitination of BECN1, a key [...] (798 aa)
     
      0.510
RIPK4
Receptor-interacting serine-threonine kinase 4 (784 aa)
     
 
  0.509
MED1
Mediator complex subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed-10406464, PubMed-11867769, PubMed-12037571, Pu [...] (1581 aa)
       
      0.503
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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