node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC138 | CCDC14 | ENSP00000295124 | ENSP00000420180 | Coiled-coil domain containing 138. | Coiled-coil domain-containing protein 14; Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. | 0.594 |
CCDC138 | CCDC22 | ENSP00000295124 | ENSP00000365401 | Coiled-coil domain containing 138. | Coiled-coil domain-containing protein 22; Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Component of the CCC complex, which is inv [...] | 0.559 |
CCDC138 | CCDC61 | ENSP00000295124 | ENSP00000471454 | Coiled-coil domain containing 138. | Coiled-coil domain containing 61. | 0.591 |
CCDC138 | FOPNL | ENSP00000295124 | ENSP00000461830 | Coiled-coil domain containing 138. | LisH domain-containing protein FOPNL; Involved in the biogenesis of cilia. Required for the recruitment of PLK1 to centrosomes and S phase progression. | 0.533 |
CCDC138 | OFD1 | ENSP00000295124 | ENSP00000344314 | Coiled-coil domain containing 138. | Oral-facial-digital syndrome 1 protein; Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriol [...] | 0.548 |
CCDC138 | PIBF1 | ENSP00000295124 | ENSP00000317144 | Coiled-coil domain containing 138. | Progesterone-induced-blocking factor 1; Plays a role in ciliogenesis. [Isoform 4]: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual naturakl killer cells (NK) activity exerts an anti-abortive effect. Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein. | 0.640 |
CCDC138 | SSX2IP | ENSP00000295124 | ENSP00000340279 | Coiled-coil domain containing 138. | Afadin- and alpha-actinin-binding protein; Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin- catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha- actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via [...] | 0.558 |
CCDC138 | TBC1D31 | ENSP00000295124 | ENSP00000287380 | Coiled-coil domain containing 138. | TBC1 domain family member 31. | 0.620 |
CCDC138 | TTLL10 | ENSP00000295124 | ENSP00000368592 | Coiled-coil domain containing 138. | Inactive polyglycylase TTLL10; Inactive polyglycylase. | 0.569 |
CCDC138 | TTLL5 | ENSP00000295124 | ENSP00000298832 | Coiled-coil domain containing 138. | Tubulin polyglutamylase TTLL5; Polyglutamylase which preferentially modifies alpha-tubulin (By similarity). Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction. Belongs to the tubulin--tyrosine ligase family. | 0.576 |
CCDC14 | CCDC138 | ENSP00000420180 | ENSP00000295124 | Coiled-coil domain-containing protein 14; Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. | Coiled-coil domain containing 138. | 0.594 |
CCDC14 | CCDC61 | ENSP00000420180 | ENSP00000471454 | Coiled-coil domain-containing protein 14; Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. | Coiled-coil domain containing 61. | 0.403 |
CCDC14 | FOPNL | ENSP00000420180 | ENSP00000461830 | Coiled-coil domain-containing protein 14; Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. | LisH domain-containing protein FOPNL; Involved in the biogenesis of cilia. Required for the recruitment of PLK1 to centrosomes and S phase progression. | 0.532 |
CCDC14 | OFD1 | ENSP00000420180 | ENSP00000344314 | Coiled-coil domain-containing protein 14; Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. | Oral-facial-digital syndrome 1 protein; Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriol [...] | 0.859 |
CCDC14 | PIBF1 | ENSP00000420180 | ENSP00000317144 | Coiled-coil domain-containing protein 14; Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. | Progesterone-induced-blocking factor 1; Plays a role in ciliogenesis. [Isoform 4]: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual naturakl killer cells (NK) activity exerts an anti-abortive effect. Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein. | 0.864 |
CCDC14 | SSX2IP | ENSP00000420180 | ENSP00000340279 | Coiled-coil domain-containing protein 14; Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. | Afadin- and alpha-actinin-binding protein; Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin- catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha- actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via [...] | 0.792 |
CCDC14 | TBC1D31 | ENSP00000420180 | ENSP00000287380 | Coiled-coil domain-containing protein 14; Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. | TBC1 domain family member 31. | 0.746 |
CCDC14 | TTLL5 | ENSP00000420180 | ENSP00000298832 | Coiled-coil domain-containing protein 14; Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. | Tubulin polyglutamylase TTLL5; Polyglutamylase which preferentially modifies alpha-tubulin (By similarity). Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction. Belongs to the tubulin--tyrosine ligase family. | 0.731 |
CCDC22 | CCDC138 | ENSP00000365401 | ENSP00000295124 | Coiled-coil domain-containing protein 22; Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Component of the CCC complex, which is inv [...] | Coiled-coil domain containing 138. | 0.559 |
CCDC61 | CCDC138 | ENSP00000471454 | ENSP00000295124 | Coiled-coil domain containing 61. | Coiled-coil domain containing 138. | 0.591 |