C1QTNF7 protein (human) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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proteins of unknown 3D structure

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALG6	C1QTNF7	ENSP00000263440	ENSP00000295297	Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.	Complement C1q tumor necrosis factor-related protein 7; C1q and TNF related 7.	0.488
ALG6	COG8	ENSP00000263440	ENSP00000497669	Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.	Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function.	0.549
ALG6	DDX51	ENSP00000263440	ENSP00000380495	Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.	ATP-dependent RNA helicase DDX51; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits; Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.	0.415
ALG6	LRRN2	ENSP00000263440	ENSP00000356143	Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.	Leucine rich repeat neuronal 2.	0.490
BAG3	C1QTNF7	ENSP00000358081	ENSP00000295297	BAG family molecular chaperone regulator 3; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Has anti- apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport.	Complement C1q tumor necrosis factor-related protein 7; C1q and TNF related 7.	0.464
C1QTNF12	C1QTNF7	ENSP00000329137	ENSP00000295297	Adipolin fC1QTNF12; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue.	Complement C1q tumor necrosis factor-related protein 7; C1q and TNF related 7.	0.572
C1QTNF7	ALG6	ENSP00000295297	ENSP00000263440	Complement C1q tumor necrosis factor-related protein 7; C1q and TNF related 7.	Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.	0.488
C1QTNF7	BAG3	ENSP00000295297	ENSP00000358081	Complement C1q tumor necrosis factor-related protein 7; C1q and TNF related 7.	BAG family molecular chaperone regulator 3; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Has anti- apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport.	0.464
C1QTNF7	C1QTNF12	ENSP00000295297	ENSP00000329137	Complement C1q tumor necrosis factor-related protein 7; C1q and TNF related 7.	Adipolin fC1QTNF12; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue.	0.572
C1QTNF7	COG8	ENSP00000295297	ENSP00000497669	Complement C1q tumor necrosis factor-related protein 7; C1q and TNF related 7.	Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function.	0.476
C1QTNF7	DDX51	ENSP00000295297	ENSP00000380495	Complement C1q tumor necrosis factor-related protein 7; C1q and TNF related 7.	ATP-dependent RNA helicase DDX51; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits; Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.	0.493
C1QTNF7	EFHB	ENSP00000295297	ENSP00000295824	Complement C1q tumor necrosis factor-related protein 7; C1q and TNF related 7.	EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus.	0.520
C1QTNF7	FBXL5	ENSP00000295297	ENSP00000344866	Complement C1q tumor necrosis factor-related protein 7; C1q and TNF related 7.	F-box/LRR-repeat protein 5; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.	0.437
C1QTNF7	LIMA1	ENSP00000295297	ENSP00000378400	Complement C1q tumor necrosis factor-related protein 7; C1q and TNF related 7.	LIM domain and actin-binding protein 1; Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments. Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, [...]	0.441
C1QTNF7	LRRN2	ENSP00000295297	ENSP00000356143	Complement C1q tumor necrosis factor-related protein 7; C1q and TNF related 7.	Leucine rich repeat neuronal 2.	0.527
C1QTNF7	TMEM69	ENSP00000295297	ENSP00000361095	Complement C1q tumor necrosis factor-related protein 7; C1q and TNF related 7.	Transmembrane protein 69.	0.535
COG8	ALG6	ENSP00000497669	ENSP00000263440	Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function.	Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.	0.549
COG8	C1QTNF7	ENSP00000497669	ENSP00000295297	Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function.	Complement C1q tumor necrosis factor-related protein 7; C1q and TNF related 7.	0.476
COG8	DDX51	ENSP00000497669	ENSP00000380495	Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function.	ATP-dependent RNA helicase DDX51; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits; Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.	0.435
COG8	LRRN2	ENSP00000497669	ENSP00000356143	Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function.	Leucine rich repeat neuronal 2.	0.480