CCDC191 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC191	CDK20	ENSP00000295878	ENSP00000322343	Coiled-coil domain containing 191.	Cyclin-dependent kinase 20; Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.	0.406
CCDC191	CDRT1	ENSP00000295878	ENSP00000379242	Coiled-coil domain containing 191.	CMT1A duplicated region transcript 1.	0.465
CCDC191	CETN1	ENSP00000295878	ENSP00000319052	Coiled-coil domain containing 191.	Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function. Plays a role in sperm cilia formation (By similarity).	0.504
CCDC191	FAM92B	ENSP00000295878	ENSP00000443411	Coiled-coil domain containing 191.	Protein FAM92B; May play a role in ciliogenesis (By similarity). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis.	0.404
CCDC191	FAM9C	ENSP00000295878	ENSP00000334430	Coiled-coil domain containing 191.	Protein FAM9C; Family with sequence similarity 9 member C.	0.444
CCDC191	LNX1	ENSP00000295878	ENSP00000263925	Coiled-coil domain containing 191.	E3 ubiquitin-protein ligase LNX; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.	0.426
CCDC191	PLEC	ENSP00000295878	ENSP00000323856	Coiled-coil domain containing 191.	Plectin; Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity.	0.566
CCDC191	RRBP1	ENSP00000295878	ENSP00000367038	Coiled-coil domain containing 191.	Ribosome binding protein 1.	0.821
CCDC191	STK24	ENSP00000295878	ENSP00000365730	Coiled-coil domain containing 191.	Serine/threonine-protein kinase 24 12 kDa subunit; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr [...]	0.410
CDK20	CCDC191	ENSP00000322343	ENSP00000295878	Cyclin-dependent kinase 20; Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.	Coiled-coil domain containing 191.	0.406
CDRT1	CCDC191	ENSP00000379242	ENSP00000295878	CMT1A duplicated region transcript 1.	Coiled-coil domain containing 191.	0.465
CETN1	CCDC191	ENSP00000319052	ENSP00000295878	Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function. Plays a role in sperm cilia formation (By similarity).	Coiled-coil domain containing 191.	0.504
FAM92B	CCDC191	ENSP00000443411	ENSP00000295878	Protein FAM92B; May play a role in ciliogenesis (By similarity). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis.	Coiled-coil domain containing 191.	0.404
FAM9C	CCDC191	ENSP00000334430	ENSP00000295878	Protein FAM9C; Family with sequence similarity 9 member C.	Coiled-coil domain containing 191.	0.444
LNX1	CCDC191	ENSP00000263925	ENSP00000295878	E3 ubiquitin-protein ligase LNX; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.	Coiled-coil domain containing 191.	0.426
PLEC	CCDC191	ENSP00000323856	ENSP00000295878	Plectin; Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity.	Coiled-coil domain containing 191.	0.566
RRBP1	CCDC191	ENSP00000367038	ENSP00000295878	Ribosome binding protein 1.	Coiled-coil domain containing 191.	0.821
STK24	CCDC191	ENSP00000365730	ENSP00000295878	Serine/threonine-protein kinase 24 12 kDa subunit; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr [...]	Coiled-coil domain containing 191.	0.410