C3orf67 protein (human) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C3orf67	CCDC113	ENSP00000295966	ENSP00000219299	Uncharacterized protein C3orf67.	Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation.	0.545
C3orf67	CCDC65	ENSP00000295966	ENSP00000312706	Uncharacterized protein C3orf67.	Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. Belongs to the DRC2 family.	0.592
C3orf67	CFAP77	ENSP00000295966	ENSP00000343290	Uncharacterized protein C3orf67.	Cilia and flagella associated protein 77.	0.529
C3orf67	EFHB	ENSP00000295966	ENSP00000295824	Uncharacterized protein C3orf67.	EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus.	0.646
C3orf67	EFHC1	ENSP00000295966	ENSP00000360107	Uncharacterized protein C3orf67.	EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death.	0.545
C3orf67	EFHC2	ENSP00000295966	ENSP00000404232	Uncharacterized protein C3orf67.	EF-hand domain-containing family member C2; EF-hand domain containing 2.	0.545
C3orf67	ENKUR	ENSP00000295966	ENSP00000331044	Uncharacterized protein C3orf67.	Enkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel.	0.694
C3orf67	PACRG	ENSP00000295966	ENSP00000337946	Uncharacterized protein C3orf67.	Parkin coregulated gene protein; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.	0.566
C3orf67	PACRGL	ENSP00000295966	ENSP00000423881	Uncharacterized protein C3orf67.	PACRG-like protein; Parkin coregulated like.	0.566
C3orf67	SPAG8	ENSP00000295966	ENSP00000340982	Uncharacterized protein C3orf67.	Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9.	0.576
CCDC113	C3orf67	ENSP00000219299	ENSP00000295966	Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation.	Uncharacterized protein C3orf67.	0.545
CCDC113	CCDC65	ENSP00000219299	ENSP00000312706	Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation.	Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. Belongs to the DRC2 family.	0.983
CCDC113	CFAP77	ENSP00000219299	ENSP00000343290	Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation.	Cilia and flagella associated protein 77.	0.429
CCDC113	EFHB	ENSP00000219299	ENSP00000295824	Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation.	EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus.	0.966
CCDC113	EFHC1	ENSP00000219299	ENSP00000360107	Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation.	EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death.	0.950
CCDC113	EFHC2	ENSP00000219299	ENSP00000404232	Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation.	EF-hand domain-containing family member C2; EF-hand domain containing 2.	0.925
CCDC113	ENKUR	ENSP00000219299	ENSP00000331044	Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation.	Enkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel.	0.977
CCDC113	PACRG	ENSP00000219299	ENSP00000337946	Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation.	Parkin coregulated gene protein; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.	0.743
CCDC113	PACRGL	ENSP00000219299	ENSP00000423881	Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation.	PACRG-like protein; Parkin coregulated like.	0.743
CCDC113	SPAG8	ENSP00000219299	ENSP00000340982	Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation.	Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9.	0.632