node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ESS2 | FRA10AC1 | ENSP00000252137 | ENSP00000360488 | Splicing factor ESS-2 homolog; May be involved in pre-mRNA splicing. | Protein FRA10AC1; FRA10A associated CGG repeat 1. | 0.831 |
ESS2 | TTC14 | ENSP00000252137 | ENSP00000296015 | Splicing factor ESS-2 homolog; May be involved in pre-mRNA splicing. | Tetratricopeptide repeat domain 14; Belongs to the TTC14 family. | 0.713 |
FRA10AC1 | ESS2 | ENSP00000360488 | ENSP00000252137 | Protein FRA10AC1; FRA10A associated CGG repeat 1. | Splicing factor ESS-2 homolog; May be involved in pre-mRNA splicing. | 0.831 |
FRA10AC1 | NKAP | ENSP00000360488 | ENSP00000360464 | Protein FRA10AC1; FRA10A associated CGG repeat 1. | NF-kappa-B-activating protein; Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF- kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter; Belongs to the NKAP family. | 0.637 |
FRA10AC1 | TTC14 | ENSP00000360488 | ENSP00000296015 | Protein FRA10AC1; FRA10A associated CGG repeat 1. | Tetratricopeptide repeat domain 14; Belongs to the TTC14 family. | 0.601 |
MCCC1 | TTC14 | ENSP00000265594 | ENSP00000296015 | Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. | Tetratricopeptide repeat domain 14; Belongs to the TTC14 family. | 0.535 |
NKAP | FRA10AC1 | ENSP00000360464 | ENSP00000360488 | NF-kappa-B-activating protein; Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF- kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter; Belongs to the NKAP family. | Protein FRA10AC1; FRA10A associated CGG repeat 1. | 0.637 |
NKAP | RBM39 | ENSP00000360464 | ENSP00000253363 | NF-kappa-B-activating protein; Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF- kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter; Belongs to the NKAP family. | RNA-binding protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process. | 0.492 |
NKAP | SNIP1 | ENSP00000360464 | ENSP00000296215 | NF-kappa-B-activating protein; Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF- kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter; Belongs to the NKAP family. | Smad nuclear-interacting protein 1; Required for pre-mRNA splicing as component of the spliceosome. Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. | 0.435 |
NKAP | SRRM2 | ENSP00000360464 | ENSP00000301740 | NF-kappa-B-activating protein; Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF- kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter; Belongs to the NKAP family. | Serine/arginine repetitive matrix protein 2; Required for pre-mRNA splicing as component of the spliceosome. Belongs to the CWC21 family. | 0.880 |
NKAP | TTC14 | ENSP00000360464 | ENSP00000296015 | NF-kappa-B-activating protein; Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF- kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter; Belongs to the NKAP family. | Tetratricopeptide repeat domain 14; Belongs to the TTC14 family. | 0.584 |
PNISR | RBM39 | ENSP00000496842 | ENSP00000253363 | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family. | RNA-binding protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process. | 0.805 |
PNISR | RNPC3 | ENSP00000496842 | ENSP00000432886 | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family. | RNA-binding region-containing protein 3; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'- stem-loop of m(7)G-capped U12 snRNA. | 0.495 |
PNISR | SRRM2 | ENSP00000496842 | ENSP00000301740 | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family. | Serine/arginine repetitive matrix protein 2; Required for pre-mRNA splicing as component of the spliceosome. Belongs to the CWC21 family. | 0.706 |
PNISR | TTC14 | ENSP00000496842 | ENSP00000296015 | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family. | Tetratricopeptide repeat domain 14; Belongs to the TTC14 family. | 0.736 |
PNISR | ZFC3H1 | ENSP00000496842 | ENSP00000368017 | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family. | Zinc finger C3H1 domain-containing protein; Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. | 0.726 |
RBM39 | NKAP | ENSP00000253363 | ENSP00000360464 | RNA-binding protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process. | NF-kappa-B-activating protein; Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF- kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter; Belongs to the NKAP family. | 0.492 |
RBM39 | PNISR | ENSP00000253363 | ENSP00000496842 | RNA-binding protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process. | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family. | 0.805 |
RBM39 | SNIP1 | ENSP00000253363 | ENSP00000296215 | RNA-binding protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process. | Smad nuclear-interacting protein 1; Required for pre-mRNA splicing as component of the spliceosome. Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. | 0.416 |
RBM39 | SRRM2 | ENSP00000253363 | ENSP00000301740 | RNA-binding protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process. | Serine/arginine repetitive matrix protein 2; Required for pre-mRNA splicing as component of the spliceosome. Belongs to the CWC21 family. | 0.926 |