TM4SF18 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLUL1	TM4SF18	ENSP00000441726	ENSP00000296059	Clusterin-like protein 1; Clusterin like 1.	Transmembrane 4 L six family member 18.	0.418
DIPK2B	ECSCR	ENSP00000381086	ENSP00000479243	Divergent protein kinase domain 2B.	Endothelial cell-specific chemotaxis regulator; Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. Belongs to the ECSCR family.	0.404
DIPK2B	TM4SF18	ENSP00000381086	ENSP00000296059	Divergent protein kinase domain 2B.	Transmembrane 4 L six family member 18.	0.469
ECSCR	DIPK2B	ENSP00000479243	ENSP00000381086	Endothelial cell-specific chemotaxis regulator; Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. Belongs to the ECSCR family.	Divergent protein kinase domain 2B.	0.404
ECSCR	TM4SF18	ENSP00000479243	ENSP00000296059	Endothelial cell-specific chemotaxis regulator; Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. Belongs to the ECSCR family.	Transmembrane 4 L six family member 18.	0.452
GIMD1	TM4SF18	ENSP00000491450	ENSP00000296059	GTPase IMAP family member GIMD1; GIMAP family P-loop NTPase domain containing 1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.	Transmembrane 4 L six family member 18.	0.571
TM4SF18	CLUL1	ENSP00000296059	ENSP00000441726	Transmembrane 4 L six family member 18.	Clusterin-like protein 1; Clusterin like 1.	0.418
TM4SF18	DIPK2B	ENSP00000296059	ENSP00000381086	Transmembrane 4 L six family member 18.	Divergent protein kinase domain 2B.	0.469
TM4SF18	ECSCR	ENSP00000296059	ENSP00000479243	Transmembrane 4 L six family member 18.	Endothelial cell-specific chemotaxis regulator; Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. Belongs to the ECSCR family.	0.452
TM4SF18	GIMD1	ENSP00000296059	ENSP00000491450	Transmembrane 4 L six family member 18.	GTPase IMAP family member GIMD1; GIMAP family P-loop NTPase domain containing 1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.	0.571
TM4SF18	TM4SF20	ENSP00000296059	ENSP00000303028	Transmembrane 4 L six family member 18.	Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein. Bel [...]	0.657
TM4SF18	TMEM65	ENSP00000296059	ENSP00000297632	Transmembrane 4 L six family member 18.	Transmembrane protein 65; May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (By similarity). May also play a role in the regulation of mitochondrial respiration and mitochondrial DNA copy number maintenance.	0.588
TM4SF20	TM4SF18	ENSP00000303028	ENSP00000296059	Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein. Bel [...]	Transmembrane 4 L six family member 18.	0.657
TMEM65	TM4SF18	ENSP00000297632	ENSP00000296059	Transmembrane protein 65; May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (By similarity). May also play a role in the regulation of mitochondrial respiration and mitochondrial DNA copy number maintenance.	Transmembrane 4 L six family member 18.	0.588