node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCZ1 | CCZ1B | ENSP00000325681 | ENSP00000314544 | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | 0.968 |
CCZ1 | GAPVD1 | ENSP00000325681 | ENSP00000377665 | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | GTPase-activating protein and VPS9 domain-containing protein 1; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside th [...] | 0.750 |
CCZ1 | MON1A | ENSP00000325681 | ENSP00000296473 | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity). Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | 0.999 |
CCZ1 | MON1B | ENSP00000325681 | ENSP00000248248 | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | MON1 homolog B, secretory trafficking associated; Belongs to the MON1/SAND family. | 0.997 |
CCZ1 | RAB5A | ENSP00000325681 | ENSP00000273047 | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] | 0.929 |
CCZ1 | RAB7A | ENSP00000325681 | ENSP00000265062 | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulat [...] | 0.914 |
CCZ1 | RABGEF1 | ENSP00000325681 | ENSP00000370208 | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | Rab5 GDP/GTP exchange factor; Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity). | 0.808 |
CCZ1 | RMC1 | ENSP00000325681 | ENSP00000269221 | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | Regulator of MON1-CCZ1 complex; Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization. | 0.990 |
CCZ1 | VPS39 | ENSP00000325681 | ENSP00000335193 | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | Vam6/Vps39-like protein; Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2- dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation. | 0.957 |
CCZ1 | VPS41 | ENSP00000325681 | ENSP00000309457 | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal me [...] | 0.929 |
CCZ1B | CCZ1 | ENSP00000314544 | ENSP00000325681 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | 0.968 |
CCZ1B | GAPVD1 | ENSP00000314544 | ENSP00000377665 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | GTPase-activating protein and VPS9 domain-containing protein 1; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside th [...] | 0.749 |
CCZ1B | MON1A | ENSP00000314544 | ENSP00000296473 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity). Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | 0.999 |
CCZ1B | MON1B | ENSP00000314544 | ENSP00000248248 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | MON1 homolog B, secretory trafficking associated; Belongs to the MON1/SAND family. | 0.985 |
CCZ1B | RAB5A | ENSP00000314544 | ENSP00000273047 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] | 0.926 |
CCZ1B | RAB7A | ENSP00000314544 | ENSP00000265062 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulat [...] | 0.908 |
CCZ1B | RABGEF1 | ENSP00000314544 | ENSP00000370208 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | Rab5 GDP/GTP exchange factor; Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity). | 0.806 |
CCZ1B | RMC1 | ENSP00000314544 | ENSP00000269221 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | Regulator of MON1-CCZ1 complex; Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization. | 0.999 |
CCZ1B | VPS39 | ENSP00000314544 | ENSP00000335193 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | Vam6/Vps39-like protein; Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2- dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation. | 0.957 |
CCZ1B | VPS41 | ENSP00000314544 | ENSP00000309457 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal me [...] | 0.928 |