node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CFTR | CTRC | ENSP00000003084 | ENSP00000365116 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Plays an important role in airway fluid homeostasis. Contributes to the regulation of the pH [...] | Chymotrypsin-C; Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity. | 0.774 |
CFTR | PRSS1 | ENSP00000003084 | ENSP00000308720 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Plays an important role in airway fluid homeostasis. Contributes to the regulation of the pH [...] | Alpha-trypsin chain 1; Has activity against the synthetic substrates Boc-Phe-Ser- Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg- Mec. The single-chain form is more active than the two-chain form against all of these substrates; Belongs to the peptidase S1 family. | 0.854 |
CFTR | PRSS2 | ENSP00000003084 | ENSP00000488437 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Plays an important role in airway fluid homeostasis. Contributes to the regulation of the pH [...] | Trypsin-2; In the ileum, may be involved in defensin processing, including DEFA5; Belongs to the peptidase S1 family. | 0.707 |
CFTR | PRSS3 | ENSP00000003084 | ENSP00000354280 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Plays an important role in airway fluid homeostasis. Contributes to the regulation of the pH [...] | Trypsin-3; Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors. Belongs to the peptidase S1 family. | 0.477 |
CFTR | PRSS58 | ENSP00000003084 | ENSP00000446916 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Plays an important role in airway fluid homeostasis. Contributes to the regulation of the pH [...] | Serine protease 58; Belongs to the peptidase S1 family. | 0.696 |
CFTR | SPINK1 | ENSP00000003084 | ENSP00000296695 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Plays an important role in airway fluid homeostasis. Contributes to the regulation of the pH [...] | Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin- catalyzed premature activation of zymogens (By similarity). | 0.888 |
CTRB1 | CTRB2 | ENSP00000354294 | ENSP00000303963 | Chymotrypsinogen B1; Belongs to the peptidase S1 family. | Chymotrypsinogen B2; Belongs to the peptidase S1 family. | 0.949 |
CTRB1 | CTRC | ENSP00000354294 | ENSP00000365116 | Chymotrypsinogen B1; Belongs to the peptidase S1 family. | Chymotrypsin-C; Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity. | 0.483 |
CTRB1 | PRSS1 | ENSP00000354294 | ENSP00000308720 | Chymotrypsinogen B1; Belongs to the peptidase S1 family. | Alpha-trypsin chain 1; Has activity against the synthetic substrates Boc-Phe-Ser- Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg- Mec. The single-chain form is more active than the two-chain form against all of these substrates; Belongs to the peptidase S1 family. | 0.863 |
CTRB1 | PRSS2 | ENSP00000354294 | ENSP00000488437 | Chymotrypsinogen B1; Belongs to the peptidase S1 family. | Trypsin-2; In the ileum, may be involved in defensin processing, including DEFA5; Belongs to the peptidase S1 family. | 0.720 |
CTRB1 | PRSS3 | ENSP00000354294 | ENSP00000354280 | Chymotrypsinogen B1; Belongs to the peptidase S1 family. | Trypsin-3; Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors. Belongs to the peptidase S1 family. | 0.798 |
CTRB1 | SPINK1 | ENSP00000354294 | ENSP00000296695 | Chymotrypsinogen B1; Belongs to the peptidase S1 family. | Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin- catalyzed premature activation of zymogens (By similarity). | 0.885 |
CTRB2 | CTRB1 | ENSP00000303963 | ENSP00000354294 | Chymotrypsinogen B2; Belongs to the peptidase S1 family. | Chymotrypsinogen B1; Belongs to the peptidase S1 family. | 0.949 |
CTRB2 | CTRC | ENSP00000303963 | ENSP00000365116 | Chymotrypsinogen B2; Belongs to the peptidase S1 family. | Chymotrypsin-C; Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity. | 0.618 |
CTRB2 | PRSS1 | ENSP00000303963 | ENSP00000308720 | Chymotrypsinogen B2; Belongs to the peptidase S1 family. | Alpha-trypsin chain 1; Has activity against the synthetic substrates Boc-Phe-Ser- Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg- Mec. The single-chain form is more active than the two-chain form against all of these substrates; Belongs to the peptidase S1 family. | 0.859 |
CTRB2 | PRSS2 | ENSP00000303963 | ENSP00000488437 | Chymotrypsinogen B2; Belongs to the peptidase S1 family. | Trypsin-2; In the ileum, may be involved in defensin processing, including DEFA5; Belongs to the peptidase S1 family. | 0.530 |
CTRB2 | PRSS3 | ENSP00000303963 | ENSP00000354280 | Chymotrypsinogen B2; Belongs to the peptidase S1 family. | Trypsin-3; Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors. Belongs to the peptidase S1 family. | 0.801 |
CTRB2 | SPINK1 | ENSP00000303963 | ENSP00000296695 | Chymotrypsinogen B2; Belongs to the peptidase S1 family. | Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin- catalyzed premature activation of zymogens (By similarity). | 0.886 |
CTRC | CFTR | ENSP00000365116 | ENSP00000003084 | Chymotrypsin-C; Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity. | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Plays an important role in airway fluid homeostasis. Contributes to the regulation of the pH [...] | 0.774 |
CTRC | CTRB1 | ENSP00000365116 | ENSP00000354294 | Chymotrypsin-C; Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity. | Chymotrypsinogen B1; Belongs to the peptidase S1 family. | 0.483 |