SPATA48 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDADC1	SPATA48	ENSP00000251108	ENSP00000297001	Cytidine and dCMP deaminase domain-containing protein 1; May play an important role in testicular development and spermatogenesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Spermatogenesis-associated protein 48; Spermatogenesis associated 48.	0.542
EFHB	SPATA48	ENSP00000295824	ENSP00000297001	EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus.	Spermatogenesis-associated protein 48; Spermatogenesis associated 48.	0.555
EFHB	TCTE1	ENSP00000295824	ENSP00000360560	EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus.	Dynein regulatory complex subunit 5; Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. May play a role in the assembly of N-DRC. May be required for sperm motility.	0.861
EFHB	TEKT3	ENSP00000295824	ENSP00000379263	EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus.	Tektin-3; May be a structural component of the sperm flagellum. Required for normal sperm mobility.	0.950
EFHB	TEX37	ENSP00000295824	ENSP00000307142	EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus.	Testis-expressed sequence 37 protein; Testis expressed 37.	0.713
KBTBD12	KLHDC8B	ENSP00000385957	ENSP00000327468	Kelch repeat and BTB domain containing 12.	Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells.	0.595
KBTBD12	PRR35	ENSP00000385957	ENSP00000386499	Kelch repeat and BTB domain containing 12.	Proline-rich protein 35; Proline rich 35.	0.597
KBTBD12	RRP36	ENSP00000385957	ENSP00000244496	Kelch repeat and BTB domain containing 12.	Ribosomal RNA processing protein 36 homolog; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA. Belongs to the RRP36 family.	0.544
KBTBD12	SPATA48	ENSP00000385957	ENSP00000297001	Kelch repeat and BTB domain containing 12.	Spermatogenesis-associated protein 48; Spermatogenesis associated 48.	0.511
KLHDC8B	KBTBD12	ENSP00000327468	ENSP00000385957	Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells.	Kelch repeat and BTB domain containing 12.	0.595
KLHDC8B	PRR35	ENSP00000327468	ENSP00000386499	Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells.	Proline-rich protein 35; Proline rich 35.	0.570
KLHDC8B	RRP36	ENSP00000327468	ENSP00000244496	Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells.	Ribosomal RNA processing protein 36 homolog; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA. Belongs to the RRP36 family.	0.513
KLHDC8B	SPATA48	ENSP00000327468	ENSP00000297001	Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells.	Spermatogenesis-associated protein 48; Spermatogenesis associated 48.	0.513
PRR35	KBTBD12	ENSP00000386499	ENSP00000385957	Proline-rich protein 35; Proline rich 35.	Kelch repeat and BTB domain containing 12.	0.597
PRR35	KLHDC8B	ENSP00000386499	ENSP00000327468	Proline-rich protein 35; Proline rich 35.	Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells.	0.570
PRR35	RRP36	ENSP00000386499	ENSP00000244496	Proline-rich protein 35; Proline rich 35.	Ribosomal RNA processing protein 36 homolog; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA. Belongs to the RRP36 family.	0.607
PRR35	SPATA48	ENSP00000386499	ENSP00000297001	Proline-rich protein 35; Proline rich 35.	Spermatogenesis-associated protein 48; Spermatogenesis associated 48.	0.615
RRP36	KBTBD12	ENSP00000244496	ENSP00000385957	Ribosomal RNA processing protein 36 homolog; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA. Belongs to the RRP36 family.	Kelch repeat and BTB domain containing 12.	0.544
RRP36	KLHDC8B	ENSP00000244496	ENSP00000327468	Ribosomal RNA processing protein 36 homolog; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA. Belongs to the RRP36 family.	Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells.	0.513
RRP36	PRR35	ENSP00000244496	ENSP00000386499	Ribosomal RNA processing protein 36 homolog; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA. Belongs to the RRP36 family.	Proline-rich protein 35; Proline rich 35.	0.607