C8orf48 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

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experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AOAH	C8orf48	ENSP00000479664	ENSP00000297324	Acyloxyacyl hydrolase large subunit; Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides. By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (By similarity). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (By similarity).	Uncharacterized protein C8orf48; Chromosome 8 open reading frame 48.	0.451
AOAH	GPR141	ENSP00000479664	ENSP00000390410	Acyloxyacyl hydrolase large subunit; Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides. By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (By similarity). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (By similarity).	Probable G-protein coupled receptor 141; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.	0.453
AOAH	TRMT9B	ENSP00000479664	ENSP00000432695	Acyloxyacyl hydrolase large subunit; Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides. By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (By similarity). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (By similarity).	Probable tRNA methyltransferase 9B; May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9.	0.517
C6orf132	C8orf48	ENSP00000341368	ENSP00000297324	Uncharacterized protein C6orf132; Chromosome 6 open reading frame 132.	Uncharacterized protein C8orf48; Chromosome 8 open reading frame 48.	0.569
C8orf48	AOAH	ENSP00000297324	ENSP00000479664	Uncharacterized protein C8orf48; Chromosome 8 open reading frame 48.	Acyloxyacyl hydrolase large subunit; Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides. By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (By similarity). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (By similarity).	0.451
C8orf48	C6orf132	ENSP00000297324	ENSP00000341368	Uncharacterized protein C8orf48; Chromosome 8 open reading frame 48.	Uncharacterized protein C6orf132; Chromosome 6 open reading frame 132.	0.569
C8orf48	DLC1	ENSP00000297324	ENSP00000276297	Uncharacterized protein C8orf48; Chromosome 8 open reading frame 48.	Rho GTPase-activating protein 7; Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.	0.484
C8orf48	EPDR1	ENSP00000297324	ENSP00000199448	Uncharacterized protein C8orf48; Chromosome 8 open reading frame 48.	Mammalian ependymin-related protein 1; Binds anionic lipids and gangliosides at acidic pH. Belongs to the ependymin family.	0.489
C8orf48	FAM86B2	ENSP00000297324	ENSP00000262365	Uncharacterized protein C8orf48; Chromosome 8 open reading frame 48.	Putative protein N-methyltransferase FAM86B2; Family with sequence similarity 86 member B2.	0.470
C8orf48	GPR141	ENSP00000297324	ENSP00000390410	Uncharacterized protein C8orf48; Chromosome 8 open reading frame 48.	Probable G-protein coupled receptor 141; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.	0.544
C8orf48	LONRF1	ENSP00000297324	ENSP00000381298	Uncharacterized protein C8orf48; Chromosome 8 open reading frame 48.	LON peptidase N-terminal domain and ring finger 1.	0.644
C8orf48	MDFI	ENSP00000297324	ENSP00000230321	Uncharacterized protein C8orf48; Chromosome 8 open reading frame 48.	MyoD family inhibitor; Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA- binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the l [...]	0.571
C8orf48	TRMT9B	ENSP00000297324	ENSP00000432695	Uncharacterized protein C8orf48; Chromosome 8 open reading frame 48.	Probable tRNA methyltransferase 9B; May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9.	0.645
C8orf48	ZNF878	ENSP00000297324	ENSP00000447931	Uncharacterized protein C8orf48; Chromosome 8 open reading frame 48.	Zinc finger protein 878; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.	0.441
DLC1	C8orf48	ENSP00000276297	ENSP00000297324	Rho GTPase-activating protein 7; Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.	Uncharacterized protein C8orf48; Chromosome 8 open reading frame 48.	0.484
DLC1	TRMT9B	ENSP00000276297	ENSP00000432695	Rho GTPase-activating protein 7; Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.	Probable tRNA methyltransferase 9B; May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9.	0.486
EPDR1	C8orf48	ENSP00000199448	ENSP00000297324	Mammalian ependymin-related protein 1; Binds anionic lipids and gangliosides at acidic pH. Belongs to the ependymin family.	Uncharacterized protein C8orf48; Chromosome 8 open reading frame 48.	0.489
EPDR1	GPR141	ENSP00000199448	ENSP00000390410	Mammalian ependymin-related protein 1; Binds anionic lipids and gangliosides at acidic pH. Belongs to the ependymin family.	Probable G-protein coupled receptor 141; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.	0.486
FAM86B2	C8orf48	ENSP00000262365	ENSP00000297324	Putative protein N-methyltransferase FAM86B2; Family with sequence similarity 86 member B2.	Uncharacterized protein C8orf48; Chromosome 8 open reading frame 48.	0.470
GPR141	AOAH	ENSP00000390410	ENSP00000479664	Probable G-protein coupled receptor 141; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.	Acyloxyacyl hydrolase large subunit; Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides. By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (By similarity). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (By similarity).	0.453