node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AASDHPPT | CNTNAP3 | ENSP00000278618 | ENSP00000297668 | L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN. | Contactin-associated protein-like 3; Contactin associated protein family member 3. | 0.593 |
AASDHPPT | CNTNAP3B | ENSP00000278618 | ENSP00000478671 | L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN. | Contactin-associated protein-like 3B; Contactin associated protein family member 3B; Belongs to the neurexin family. | 0.591 |
APBA1 | CNTNAP3 | ENSP00000265381 | ENSP00000297668 | Amyloid-beta A4 precursor protein-binding family A member 1; Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. | Contactin-associated protein-like 3; Contactin associated protein family member 3. | 0.783 |
APBA1 | EPB41 | ENSP00000265381 | ENSP00000345259 | Amyloid-beta A4 precursor protein-binding family A member 1; Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. | Protein 4.1; Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase. | 0.485 |
BABAM1 | CNTNAP3 | ENSP00000352408 | ENSP00000297668 | BRISC and BRCA1-A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cl [...] | Contactin-associated protein-like 3; Contactin associated protein family member 3. | 0.417 |
BABAM1 | KANK2 | ENSP00000352408 | ENSP00000468002 | BRISC and BRCA1-A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cl [...] | KN motif and ankyrin repeat domain-containing protein 2; Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3. Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria. Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis. Involved in the negative control of vitamin D receptor signaling pathway. Involved in actin stress fibers formation through its interaction with ARHGDI [...] | 0.445 |
CNTN3 | CNTNAP3 | ENSP00000263665 | ENSP00000297668 | Contactin-3; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity); Belongs to the immunoglobulin superfamily. Contactin family. | Contactin-associated protein-like 3; Contactin associated protein family member 3. | 0.437 |
CNTN3 | EGF | ENSP00000263665 | ENSP00000265171 | Contactin-3; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity); Belongs to the immunoglobulin superfamily. Contactin family. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro. | 0.414 |
CNTNAP3 | AASDHPPT | ENSP00000297668 | ENSP00000278618 | Contactin-associated protein-like 3; Contactin associated protein family member 3. | L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN. | 0.593 |
CNTNAP3 | APBA1 | ENSP00000297668 | ENSP00000265381 | Contactin-associated protein-like 3; Contactin associated protein family member 3. | Amyloid-beta A4 precursor protein-binding family A member 1; Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. | 0.783 |
CNTNAP3 | BABAM1 | ENSP00000297668 | ENSP00000352408 | Contactin-associated protein-like 3; Contactin associated protein family member 3. | BRISC and BRCA1-A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cl [...] | 0.417 |
CNTNAP3 | CNTN3 | ENSP00000297668 | ENSP00000263665 | Contactin-associated protein-like 3; Contactin associated protein family member 3. | Contactin-3; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity); Belongs to the immunoglobulin superfamily. Contactin family. | 0.437 |
CNTNAP3 | CNTNAP3B | ENSP00000297668 | ENSP00000478671 | Contactin-associated protein-like 3; Contactin associated protein family member 3. | Contactin-associated protein-like 3B; Contactin associated protein family member 3B; Belongs to the neurexin family. | 0.605 |
CNTNAP3 | CREB5 | ENSP00000297668 | ENSP00000350359 | Contactin-associated protein-like 3; Contactin associated protein family member 3. | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. | 0.469 |
CNTNAP3 | EGF | ENSP00000297668 | ENSP00000265171 | Contactin-associated protein-like 3; Contactin associated protein family member 3. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro. | 0.402 |
CNTNAP3 | EPB41 | ENSP00000297668 | ENSP00000345259 | Contactin-associated protein-like 3; Contactin associated protein family member 3. | Protein 4.1; Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase. | 0.693 |
CNTNAP3 | KANK2 | ENSP00000297668 | ENSP00000468002 | Contactin-associated protein-like 3; Contactin associated protein family member 3. | KN motif and ankyrin repeat domain-containing protein 2; Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3. Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria. Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis. Involved in the negative control of vitamin D receptor signaling pathway. Involved in actin stress fibers formation through its interaction with ARHGDI [...] | 0.424 |
CNTNAP3B | AASDHPPT | ENSP00000478671 | ENSP00000278618 | Contactin-associated protein-like 3B; Contactin associated protein family member 3B; Belongs to the neurexin family. | L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN. | 0.591 |
CNTNAP3B | CNTNAP3 | ENSP00000478671 | ENSP00000297668 | Contactin-associated protein-like 3B; Contactin associated protein family member 3B; Belongs to the neurexin family. | Contactin-associated protein-like 3; Contactin associated protein family member 3. | 0.605 |
CREB5 | CNTNAP3 | ENSP00000350359 | ENSP00000297668 | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. | Contactin-associated protein-like 3; Contactin associated protein family member 3. | 0.469 |