node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CUL4B | ZMAT4 | ENSP00000384109 | ENSP00000297737 | Cullin-4B; Core component of multiple cullin-RING-based E3 ubiquitin- protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and [...] | Zinc finger matrin-type 4. | 0.497 |
FAM110A | TM2D2 | ENSP00000354163 | ENSP00000416050 | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family. | TM2 domain containing 2. | 0.510 |
FAM110A | ZMAT4 | ENSP00000354163 | ENSP00000297737 | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family. | Zinc finger matrin-type 4. | 0.489 |
GJD2 | PRSS56 | ENSP00000290374 | ENSP00000479745 | Gap junction delta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Delta-type subfamily. | Serine protease 56; Serine protease required during eye development. | 0.525 |
GJD2 | ZMAT4 | ENSP00000290374 | ENSP00000297737 | Gap junction delta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Delta-type subfamily. | Zinc finger matrin-type 4. | 0.573 |
ITPRID1 | ZMAT4 | ENSP00000395835 | ENSP00000297737 | Protein ITPRID1; ITPR interacting domain containing 1. | Zinc finger matrin-type 4. | 0.508 |
PRKRA | TARBP2 | ENSP00000318176 | ENSP00000266987 | Interferon-inducible double-stranded RNA-dependent protein kinase activator A; Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys- 386' at 'Ser-392' respectively and enhances its activity [...] | RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] | 0.994 |
PRKRA | ZMAT4 | ENSP00000318176 | ENSP00000297737 | Interferon-inducible double-stranded RNA-dependent protein kinase activator A; Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys- 386' at 'Ser-392' respectively and enhances its activity [...] | Zinc finger matrin-type 4. | 0.608 |
PRSS56 | GJD2 | ENSP00000479745 | ENSP00000290374 | Serine protease 56; Serine protease required during eye development. | Gap junction delta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Delta-type subfamily. | 0.525 |
PRSS56 | SHISA6 | ENSP00000479745 | ENSP00000390084 | Serine protease 56; Serine protease required during eye development. | Protein shisa-6; Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway. | 0.555 |
PRSS56 | ZMAT4 | ENSP00000479745 | ENSP00000297737 | Serine protease 56; Serine protease required during eye development. | Zinc finger matrin-type 4. | 0.476 |
SHISA6 | PRSS56 | ENSP00000390084 | ENSP00000479745 | Protein shisa-6; Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway. | Serine protease 56; Serine protease required during eye development. | 0.555 |
SHISA6 | ZMAT4 | ENSP00000390084 | ENSP00000297737 | Protein shisa-6; Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway. | Zinc finger matrin-type 4. | 0.477 |
TARBP2 | PRKRA | ENSP00000266987 | ENSP00000318176 | RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] | Interferon-inducible double-stranded RNA-dependent protein kinase activator A; Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys- 386' at 'Ser-392' respectively and enhances its activity [...] | 0.994 |
TARBP2 | ZMAT4 | ENSP00000266987 | ENSP00000297737 | RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] | Zinc finger matrin-type 4. | 0.566 |
TM2D2 | FAM110A | ENSP00000416050 | ENSP00000354163 | TM2 domain containing 2. | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family. | 0.510 |
TM2D2 | ZMAT4 | ENSP00000416050 | ENSP00000297737 | TM2 domain containing 2. | Zinc finger matrin-type 4. | 0.489 |
USHBP1 | ZMAT4 | ENSP00000252597 | ENSP00000297737 | Usher syndrome type-1C protein-binding protein 1; USH1 protein network component harmonin binding protein 1. | Zinc finger matrin-type 4. | 0.534 |
ZMAT4 | CUL4B | ENSP00000297737 | ENSP00000384109 | Zinc finger matrin-type 4. | Cullin-4B; Core component of multiple cullin-RING-based E3 ubiquitin- protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and [...] | 0.497 |
ZMAT4 | FAM110A | ENSP00000297737 | ENSP00000354163 | Zinc finger matrin-type 4. | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family. | 0.489 |