STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CXorf22Cilia- and flagella-associated protein 47; Chromosome X open reading frame 22 (976 aa)    
Predicted Functional Partners:
RPS6KA6
Ribosomal protein S6 kinase alpha-6; Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily
   
  
 0.755
CCDC108
Cilia- and flagella-associated protein 65; May play a role in sperm motility; Belongs to the CFAP65 family
   
  
 0.755
PCDH11X
Protocadherin-11 X-linked; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins
   
  
 0.717
CYLC1
Cylicin-1; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation
   
    0.674
TRAPPC11
Trafficking protein particle complex subunit 11; Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage; Trafficking protein particle complex
      
 0.628
DLEC1
Deleted in lung and esophageal cancer protein 1; May act as a tumor suppressor by inhibiting cell proliferation; Cilia and flagella associated
   
  
 0.611
LANCL3
LanC-like protein 3; LanC like 3
      
 0.592
MAGEB16
Melanoma-associated antigen B16; MAGE family member B16
      
 0.586
TRAPPC8
Trafficking protein particle complex subunit 8; May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage; Trafficking protein particle complex
      
 0.578
EFHC2
EF-hand domain-containing family member C2; EF-hand domain containing 2
   
    0.569
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.