LRRC18 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCC2	LRRC18	ENSP00000380877	ENSP00000363275	Activating signal cointegrator 1 complex subunit 2; Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains. Part of the ASC-1 complex that enhances NF- kappa-B, SRF and AP1 transactivation.	Leucine-rich repeat-containing protein 18; May be involved in the regulation of spermatogenesis and sperm maturation.	0.546
ATP6AP1L	LMNTD1	ENSP00000391381	ENSP00000407353	V-type proton ATPase subunit S1-like protein; ATPase H+ transporting accessory protein 1 like.	Lamin tail domain containing 1.	0.486
ATP6AP1L	LRRC18	ENSP00000391381	ENSP00000363275	V-type proton ATPase subunit S1-like protein; ATPase H+ transporting accessory protein 1 like.	Leucine-rich repeat-containing protein 18; May be involved in the regulation of spermatogenesis and sperm maturation.	0.605
ATP6AP1L	LRRC74B	ENSP00000391381	ENSP00000394078	V-type proton ATPase subunit S1-like protein; ATPase H+ transporting accessory protein 1 like.	Leucine-rich repeat-containing protein 74B; Leucine rich repeat containing 74B.	0.529
CPN2	LRG1	ENSP00000319464	ENSP00000302621	Carboxypeptidase N subunit 2; The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit.	Leucine rich alpha-2-glycoprotein 1.	0.437
CPN2	LRRC18	ENSP00000319464	ENSP00000363275	Carboxypeptidase N subunit 2; The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit.	Leucine-rich repeat-containing protein 18; May be involved in the regulation of spermatogenesis and sperm maturation.	0.514
DRG2	LRRC18	ENSP00000225729	ENSP00000363275	Developmentally-regulated GTP-binding protein 2; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation.	Leucine-rich repeat-containing protein 18; May be involved in the regulation of spermatogenesis and sperm maturation.	0.565
LMNTD1	ATP6AP1L	ENSP00000407353	ENSP00000391381	Lamin tail domain containing 1.	V-type proton ATPase subunit S1-like protein; ATPase H+ transporting accessory protein 1 like.	0.486
LMNTD1	LRRC18	ENSP00000407353	ENSP00000363275	Lamin tail domain containing 1.	Leucine-rich repeat-containing protein 18; May be involved in the regulation of spermatogenesis and sperm maturation.	0.548
LMNTD1	LRRC74B	ENSP00000407353	ENSP00000394078	Lamin tail domain containing 1.	Leucine-rich repeat-containing protein 74B; Leucine rich repeat containing 74B.	0.409
LRG1	CPN2	ENSP00000302621	ENSP00000319464	Leucine rich alpha-2-glycoprotein 1.	Carboxypeptidase N subunit 2; The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit.	0.437
LRG1	LRRC18	ENSP00000302621	ENSP00000363275	Leucine rich alpha-2-glycoprotein 1.	Leucine-rich repeat-containing protein 18; May be involved in the regulation of spermatogenesis and sperm maturation.	0.522
LRRC18	ASCC2	ENSP00000363275	ENSP00000380877	Leucine-rich repeat-containing protein 18; May be involved in the regulation of spermatogenesis and sperm maturation.	Activating signal cointegrator 1 complex subunit 2; Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains. Part of the ASC-1 complex that enhances NF- kappa-B, SRF and AP1 transactivation.	0.546
LRRC18	ATP6AP1L	ENSP00000363275	ENSP00000391381	Leucine-rich repeat-containing protein 18; May be involved in the regulation of spermatogenesis and sperm maturation.	V-type proton ATPase subunit S1-like protein; ATPase H+ transporting accessory protein 1 like.	0.605
LRRC18	CPN2	ENSP00000363275	ENSP00000319464	Leucine-rich repeat-containing protein 18; May be involved in the regulation of spermatogenesis and sperm maturation.	Carboxypeptidase N subunit 2; The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit.	0.514
LRRC18	DRG2	ENSP00000363275	ENSP00000225729	Leucine-rich repeat-containing protein 18; May be involved in the regulation of spermatogenesis and sperm maturation.	Developmentally-regulated GTP-binding protein 2; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation.	0.565
LRRC18	LMNTD1	ENSP00000363275	ENSP00000407353	Leucine-rich repeat-containing protein 18; May be involved in the regulation of spermatogenesis and sperm maturation.	Lamin tail domain containing 1.	0.548
LRRC18	LRG1	ENSP00000363275	ENSP00000302621	Leucine-rich repeat-containing protein 18; May be involved in the regulation of spermatogenesis and sperm maturation.	Leucine rich alpha-2-glycoprotein 1.	0.522
LRRC18	LRRC74B	ENSP00000363275	ENSP00000394078	Leucine-rich repeat-containing protein 18; May be involved in the regulation of spermatogenesis and sperm maturation.	Leucine-rich repeat-containing protein 74B; Leucine rich repeat containing 74B.	0.591
LRRC18	LUM	ENSP00000363275	ENSP00000266718	Leucine-rich repeat-containing protein 18; May be involved in the regulation of spermatogenesis and sperm maturation.	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.514