node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MIPOL1 | SSX3 | ENSP00000333539 | ENSP00000298396 | Mirror-image polydactyly 1. | Protein SSX3; Could act as a modulator of transcription; Belongs to the SSX family. | 0.518 |
PRRG3 | SSX3 | ENSP00000359378 | ENSP00000298396 | Transmembrane gamma-carboxyglutamic acid protein 3; Proline rich and Gla domain 3. | Protein SSX3; Could act as a modulator of transcription; Belongs to the SSX family. | 0.544 |
RAB3IP | SSX1 | ENSP00000447300 | ENSP00000366118 | Rab-3A-interacting protein; Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface forma [...] | Protein SSX1; Could act as a modulator of transcription; Belongs to the SSX family. | 0.560 |
RAB3IP | SSX2 | ENSP00000447300 | ENSP00000338796 | Rab-3A-interacting protein; Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface forma [...] | SSX family member 2. | 0.730 |
RAB3IP | SSX2IP | ENSP00000447300 | ENSP00000340279 | Rab-3A-interacting protein; Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface forma [...] | Afadin- and alpha-actinin-binding protein; Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin- catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha- actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via [...] | 0.599 |
RAB3IP | SSX3 | ENSP00000447300 | ENSP00000298396 | Rab-3A-interacting protein; Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface forma [...] | Protein SSX3; Could act as a modulator of transcription; Belongs to the SSX family. | 0.630 |
SS18 | SSX1 | ENSP00000414516 | ENSP00000366118 | Protein SSXT; Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. | Protein SSX1; Could act as a modulator of transcription; Belongs to the SSX family. | 0.969 |
SS18 | SSX2 | ENSP00000414516 | ENSP00000338796 | Protein SSXT; Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. | SSX family member 2. | 0.986 |
SS18 | SSX3 | ENSP00000414516 | ENSP00000298396 | Protein SSXT; Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. | Protein SSX3; Could act as a modulator of transcription; Belongs to the SSX family. | 0.718 |
SS18 | ZNF117 | ENSP00000414516 | ENSP00000282869 | Protein SSXT; Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. | Zinc finger protein 117; May be involved in transcriptional regulation. | 0.770 |
SS18 | ZNF83 | ENSP00000414516 | ENSP00000472619 | Protein SSXT; Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. | Zinc finger protein 83; May be involved in transcriptional regulation. | 0.772 |
SSX1 | RAB3IP | ENSP00000366118 | ENSP00000447300 | Protein SSX1; Could act as a modulator of transcription; Belongs to the SSX family. | Rab-3A-interacting protein; Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface forma [...] | 0.560 |
SSX1 | SS18 | ENSP00000366118 | ENSP00000414516 | Protein SSX1; Could act as a modulator of transcription; Belongs to the SSX family. | Protein SSXT; Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. | 0.969 |
SSX1 | SSX2 | ENSP00000366118 | ENSP00000338796 | Protein SSX1; Could act as a modulator of transcription; Belongs to the SSX family. | SSX family member 2. | 0.966 |
SSX1 | SSX2IP | ENSP00000366118 | ENSP00000340279 | Protein SSX1; Could act as a modulator of transcription; Belongs to the SSX family. | Afadin- and alpha-actinin-binding protein; Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin- catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha- actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via [...] | 0.761 |
SSX1 | SSX3 | ENSP00000366118 | ENSP00000298396 | Protein SSX1; Could act as a modulator of transcription; Belongs to the SSX family. | Protein SSX3; Could act as a modulator of transcription; Belongs to the SSX family. | 0.755 |
SSX1 | ZNF117 | ENSP00000366118 | ENSP00000282869 | Protein SSX1; Could act as a modulator of transcription; Belongs to the SSX family. | Zinc finger protein 117; May be involved in transcriptional regulation. | 0.760 |
SSX1 | ZNF83 | ENSP00000366118 | ENSP00000472619 | Protein SSX1; Could act as a modulator of transcription; Belongs to the SSX family. | Zinc finger protein 83; May be involved in transcriptional regulation. | 0.760 |
SSX2 | RAB3IP | ENSP00000338796 | ENSP00000447300 | SSX family member 2. | Rab-3A-interacting protein; Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface forma [...] | 0.730 |
SSX2 | SS18 | ENSP00000338796 | ENSP00000414516 | SSX family member 2. | Protein SSXT; Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. | 0.986 |