C12orf50 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP3	C12orf50	ENSP00000228850	ENSP00000298699	A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction.	Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50.	0.513
ASH1L	C12orf50	ENSP00000376204	ENSP00000298699	Histone-lysine N-methyltransferase ASH1L; Histone methyltransferase specifically trimethylating 'Lys- 36' of histone H3 forming H3K36me3. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity); Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50.	0.562
C12orf29	C12orf50	ENSP00000349358	ENSP00000298699	Uncharacterized protein C12orf29; Chromosome 12 open reading frame 29.	Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50.	0.694
C12orf29	MGAT4C	ENSP00000349358	ENSP00000481096	Uncharacterized protein C12orf29; Chromosome 12 open reading frame 29.	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; Glycosyltransferase that participates in the transfer of N- acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity).	0.426
C12orf29	RASSF9	ENSP00000349358	ENSP00000354884	Uncharacterized protein C12orf29; Chromosome 12 open reading frame 29.	Ras association domain-containing protein 9; May play a role in regulating vesicuar trafficking in cells.	0.507
C12orf29	TMTC3	ENSP00000349358	ENSP00000266712	Uncharacterized protein C12orf29; Chromosome 12 open reading frame 29.	Protein O-mannosyl-transferase TMTC3; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl- transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O- mannosyl-transferase on other proteins such as PDIA3. Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response.	0.509
C12orf29	TSPAN19	ENSP00000349358	ENSP00000433816	Uncharacterized protein C12orf29; Chromosome 12 open reading frame 29.	Putative tetraspanin-19; Tetraspanin 19.	0.560
C12orf50	AKAP3	ENSP00000298699	ENSP00000228850	Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50.	A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction.	0.513
C12orf50	ASH1L	ENSP00000298699	ENSP00000376204	Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50.	Histone-lysine N-methyltransferase ASH1L; Histone methyltransferase specifically trimethylating 'Lys- 36' of histone H3 forming H3K36me3. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity); Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	0.562
C12orf50	C12orf29	ENSP00000298699	ENSP00000349358	Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50.	Uncharacterized protein C12orf29; Chromosome 12 open reading frame 29.	0.694
C12orf50	CCDC54	ENSP00000298699	ENSP00000261058	Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50.	Coiled-coil domain containing 54.	0.515
C12orf50	FAM71F1	ENSP00000298699	ENSP00000326652	Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50.	Protein FAM71F1; Family with sequence similarity 71 member F1.	0.525
C12orf50	MGAT4C	ENSP00000298699	ENSP00000481096	Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50.	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; Glycosyltransferase that participates in the transfer of N- acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity).	0.519
C12orf50	RASSF9	ENSP00000298699	ENSP00000354884	Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50.	Ras association domain-containing protein 9; May play a role in regulating vesicuar trafficking in cells.	0.538
C12orf50	TMCO2	ENSP00000298699	ENSP00000361852	Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50.	Transmembrane and coiled-coil domains 2.	0.528
C12orf50	TMTC3	ENSP00000298699	ENSP00000266712	Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50.	Protein O-mannosyl-transferase TMTC3; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl- transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O- mannosyl-transferase on other proteins such as PDIA3. Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response.	0.524
C12orf50	TSPAN19	ENSP00000298699	ENSP00000433816	Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50.	Putative tetraspanin-19; Tetraspanin 19.	0.591
CCDC54	C12orf50	ENSP00000261058	ENSP00000298699	Coiled-coil domain containing 54.	Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50.	0.515
CCDC54	FAM71F1	ENSP00000261058	ENSP00000326652	Coiled-coil domain containing 54.	Protein FAM71F1; Family with sequence similarity 71 member F1.	0.429
CCDC54	TMCO2	ENSP00000261058	ENSP00000361852	Coiled-coil domain containing 54.	Transmembrane and coiled-coil domains 2.	0.580