C16orf78 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C10orf82	C16orf78	ENSP00000465712	ENSP00000299191	Uncharacterized protein C10orf82; Chromosome 10 open reading frame 82.	Uncharacterized protein C16orf78; Chromosome 16 open reading frame 78.	0.468
C10orf82	CCDC83	ENSP00000465712	ENSP00000280245	Uncharacterized protein C10orf82; Chromosome 10 open reading frame 82.	Coiled-coil domain containing 83.	0.403
C16orf78	C10orf82	ENSP00000299191	ENSP00000465712	Uncharacterized protein C16orf78; Chromosome 16 open reading frame 78.	Uncharacterized protein C10orf82; Chromosome 10 open reading frame 82.	0.468
C16orf78	C16orf86	ENSP00000299191	ENSP00000384117	Uncharacterized protein C16orf78; Chromosome 16 open reading frame 78.	Uncharacterized protein C16orf86; Chromosome 16 open reading frame 86.	0.466
C16orf78	C16orf96	ENSP00000299191	ENSP00000415027	Uncharacterized protein C16orf78; Chromosome 16 open reading frame 78.	Uncharacterized protein C16orf96; Chromosome 16 open reading frame 96.	0.463
C16orf78	C19orf18	ENSP00000299191	ENSP00000321519	Uncharacterized protein C16orf78; Chromosome 16 open reading frame 78.	Uncharacterized protein C19orf18; Chromosome 19 open reading frame 18.	0.444
C16orf78	C20orf144	ENSP00000299191	ENSP00000364370	Uncharacterized protein C16orf78; Chromosome 16 open reading frame 78.	Uncharacterized protein C20orf144; Chromosome 20 open reading frame 144.	0.515
C16orf78	C22orf42	ENSP00000299191	ENSP00000371529	Uncharacterized protein C16orf78; Chromosome 16 open reading frame 78.	Uncharacterized protein C22orf42; Chromosome 22 open reading frame 42.	0.446
C16orf78	CCDC83	ENSP00000299191	ENSP00000280245	Uncharacterized protein C16orf78; Chromosome 16 open reading frame 78.	Coiled-coil domain containing 83.	0.462
C16orf78	CNEP1R1	ENSP00000299191	ENSP00000405635	Uncharacterized protein C16orf78; Chromosome 16 open reading frame 78.	Nuclear envelope phosphatase-regulatory subunit 1; Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplet [...]	0.490
C16orf78	SRPK1	ENSP00000299191	ENSP00000362931	Uncharacterized protein C16orf78; Chromosome 16 open reading frame 78.	SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...]	0.467
C16orf78	SRPK2	ENSP00000299191	ENSP00000377262	Uncharacterized protein C16orf78; Chromosome 16 open reading frame 78.	SRSF protein kinase 2 C-terminal; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates [...]	0.472
C16orf86	C16orf78	ENSP00000384117	ENSP00000299191	Uncharacterized protein C16orf86; Chromosome 16 open reading frame 86.	Uncharacterized protein C16orf78; Chromosome 16 open reading frame 78.	0.466
C16orf86	C16orf96	ENSP00000384117	ENSP00000415027	Uncharacterized protein C16orf86; Chromosome 16 open reading frame 86.	Uncharacterized protein C16orf96; Chromosome 16 open reading frame 96.	0.466
C16orf86	C19orf18	ENSP00000384117	ENSP00000321519	Uncharacterized protein C16orf86; Chromosome 16 open reading frame 86.	Uncharacterized protein C19orf18; Chromosome 19 open reading frame 18.	0.467
C16orf86	C20orf144	ENSP00000384117	ENSP00000364370	Uncharacterized protein C16orf86; Chromosome 16 open reading frame 86.	Uncharacterized protein C20orf144; Chromosome 20 open reading frame 144.	0.531
C16orf86	C22orf42	ENSP00000384117	ENSP00000371529	Uncharacterized protein C16orf86; Chromosome 16 open reading frame 86.	Uncharacterized protein C22orf42; Chromosome 22 open reading frame 42.	0.441
C16orf96	C16orf78	ENSP00000415027	ENSP00000299191	Uncharacterized protein C16orf96; Chromosome 16 open reading frame 96.	Uncharacterized protein C16orf78; Chromosome 16 open reading frame 78.	0.463
C16orf96	C16orf86	ENSP00000415027	ENSP00000384117	Uncharacterized protein C16orf96; Chromosome 16 open reading frame 96.	Uncharacterized protein C16orf86; Chromosome 16 open reading frame 86.	0.466
C16orf96	C19orf18	ENSP00000415027	ENSP00000321519	Uncharacterized protein C16orf96; Chromosome 16 open reading frame 96.	Uncharacterized protein C19orf18; Chromosome 19 open reading frame 18.	0.444