node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKAP3 | C16orf46 | ENSP00000228850 | ENSP00000299578 | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. | Uncharacterized protein C16orf46; Chromosome 16 open reading frame 46. | 0.402 |
C16orf46 | AKAP3 | ENSP00000299578 | ENSP00000228850 | Uncharacterized protein C16orf46; Chromosome 16 open reading frame 46. | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. | 0.402 |
C16orf46 | CCDC183 | ENSP00000299578 | ENSP00000338013 | Uncharacterized protein C16orf46; Chromosome 16 open reading frame 46. | Coiled-coil domain containing 183. | 0.452 |
C16orf46 | ENAM | ENSP00000299578 | ENSP00000379383 | Uncharacterized protein C16orf46; Chromosome 16 open reading frame 46. | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. | 0.487 |
C16orf46 | FAT3 | ENSP00000299578 | ENSP00000432586 | Uncharacterized protein C16orf46; Chromosome 16 open reading frame 46. | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | 0.420 |
C16orf46 | GCSH | ENSP00000299578 | ENSP00000319531 | Uncharacterized protein C16orf46; Chromosome 16 open reading frame 46. | Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Belongs to the GcvH family. | 0.539 |
C16orf46 | IGKV2D-28 | ENSP00000299578 | ENSP00000452662 | Uncharacterized protein C16orf46; Chromosome 16 open reading frame 46. | Immunoglobulin kappa variable 2-28; V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins- secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, whic [...] | 0.431 |
C16orf46 | IL22RA1 | ENSP00000299578 | ENSP00000270800 | Uncharacterized protein C16orf46; Chromosome 16 open reading frame 46. | Interleukin-22 receptor subunit alpha-1; Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. | 0.473 |
C16orf46 | PRR14L | ENSP00000299578 | ENSP00000331845 | Uncharacterized protein C16orf46; Chromosome 16 open reading frame 46. | Protein PRR14L; Proline rich 14 like. | 0.406 |
C16orf46 | SPAG5 | ENSP00000299578 | ENSP00000323300 | Uncharacterized protein C16orf46; Chromosome 16 open reading frame 46. | Sperm-associated antigen 5; Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule- kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. Involved in centriole duplication. Required for C [...] | 0.407 |
C16orf46 | TTC26 | ENSP00000299578 | ENSP00000419279 | Uncharacterized protein C16orf46; Chromosome 16 open reading frame 46. | Intraflagellar transport protein 56; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT compl [...] | 0.481 |
CCDC183 | C16orf46 | ENSP00000338013 | ENSP00000299578 | Coiled-coil domain containing 183. | Uncharacterized protein C16orf46; Chromosome 16 open reading frame 46. | 0.452 |
ENAM | C16orf46 | ENSP00000379383 | ENSP00000299578 | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. | Uncharacterized protein C16orf46; Chromosome 16 open reading frame 46. | 0.487 |
ENAM | IL22RA1 | ENSP00000379383 | ENSP00000270800 | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. | Interleukin-22 receptor subunit alpha-1; Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. | 0.404 |
ENAM | SPAG5 | ENSP00000379383 | ENSP00000323300 | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. | Sperm-associated antigen 5; Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule- kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. Involved in centriole duplication. Required for C [...] | 0.439 |
FAT3 | C16orf46 | ENSP00000432586 | ENSP00000299578 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development. | Uncharacterized protein C16orf46; Chromosome 16 open reading frame 46. | 0.420 |
GCSH | C16orf46 | ENSP00000319531 | ENSP00000299578 | Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Belongs to the GcvH family. | Uncharacterized protein C16orf46; Chromosome 16 open reading frame 46. | 0.539 |
IGKV2D-28 | C16orf46 | ENSP00000452662 | ENSP00000299578 | Immunoglobulin kappa variable 2-28; V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins- secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, whic [...] | Uncharacterized protein C16orf46; Chromosome 16 open reading frame 46. | 0.431 |
IL22RA1 | C16orf46 | ENSP00000270800 | ENSP00000299578 | Interleukin-22 receptor subunit alpha-1; Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. | Uncharacterized protein C16orf46; Chromosome 16 open reading frame 46. | 0.473 |
IL22RA1 | ENAM | ENSP00000270800 | ENSP00000379383 | Interleukin-22 receptor subunit alpha-1; Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. | 0.404 |