node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGAP11B | CHRFAM7A | ENSP00000392760 | ENSP00000299847 | Rho GTPase-activating protein 11B; Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Does not possess GTPase activator activity. | CHRNA7-FAM7A fusion protein; CHRNA7 fusion. | 0.582 |
ARHGAP11B | OTUD7A | ENSP00000392760 | ENSP00000305926 | Rho GTPase-activating protein 11B; Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Does not possess GTPase activator activity. | OTU domain-containing protein 7A; Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains; Belongs to the peptidase C64 family. | 0.628 |
ARHGAP11B-2 | CHRFAM7A | ENSP00000481934 | ENSP00000299847 | Rho GTPase activating protein 11B. | CHRNA7-FAM7A fusion protein; CHRNA7 fusion. | 0.581 |
ARHGAP11B-2 | OTUD7A | ENSP00000481934 | ENSP00000305926 | Rho GTPase activating protein 11B. | OTU domain-containing protein 7A; Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains; Belongs to the peptidase C64 family. | 0.643 |
CHRFAM7A | ARHGAP11B | ENSP00000299847 | ENSP00000392760 | CHRNA7-FAM7A fusion protein; CHRNA7 fusion. | Rho GTPase-activating protein 11B; Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Does not possess GTPase activator activity. | 0.582 |
CHRFAM7A | ARHGAP11B-2 | ENSP00000299847 | ENSP00000481934 | CHRNA7-FAM7A fusion protein; CHRNA7 fusion. | Rho GTPase activating protein 11B. | 0.581 |
CHRFAM7A | CHRNA1 | ENSP00000299847 | ENSP00000261007 | CHRNA7-FAM7A fusion protein; CHRNA7 fusion. | Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | 0.701 |
CHRFAM7A | CHRNA2 | ENSP00000299847 | ENSP00000385026 | CHRNA7-FAM7A fusion protein; CHRNA7 fusion. | Neuronal acetylcholine receptor subunit alpha-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-2/CHRNA2 sub- subfamily. | 0.582 |
CHRFAM7A | CHRNA4 | ENSP00000299847 | ENSP00000359285 | CHRNA7-FAM7A fusion protein; CHRNA7 fusion. | Neuronal acetylcholine receptor subunit alpha-4; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-4/CHRNA4 sub- subfamily. | 0.592 |
CHRFAM7A | CHRNA5 | ENSP00000299847 | ENSP00000299565 | CHRNA7-FAM7A fusion protein; CHRNA7 fusion. | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | 0.599 |
CHRFAM7A | CHRNA7 | ENSP00000299847 | ENSP00000407546 | CHRNA7-FAM7A fusion protein; CHRNA7 fusion. | Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. | 0.969 |
CHRFAM7A | CHRNB2 | ENSP00000299847 | ENSP00000357461 | CHRNA7-FAM7A fusion protein; CHRNA7 fusion. | Neuronal acetylcholine receptor subunit beta-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions. | 0.686 |
CHRFAM7A | CHRNB3 | ENSP00000299847 | ENSP00000289957 | CHRNA7-FAM7A fusion protein; CHRNA7 fusion. | Neuronal acetylcholine receptor subunit beta-3; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | 0.589 |
CHRFAM7A | OTUD7A | ENSP00000299847 | ENSP00000305926 | CHRNA7-FAM7A fusion protein; CHRNA7 fusion. | OTU domain-containing protein 7A; Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains; Belongs to the peptidase C64 family. | 0.962 |
CHRNA1 | CHRFAM7A | ENSP00000261007 | ENSP00000299847 | Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | CHRNA7-FAM7A fusion protein; CHRNA7 fusion. | 0.701 |
CHRNA1 | CHRNA2 | ENSP00000261007 | ENSP00000385026 | Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | Neuronal acetylcholine receptor subunit alpha-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-2/CHRNA2 sub- subfamily. | 0.726 |
CHRNA1 | CHRNA4 | ENSP00000261007 | ENSP00000359285 | Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | Neuronal acetylcholine receptor subunit alpha-4; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-4/CHRNA4 sub- subfamily. | 0.812 |
CHRNA1 | CHRNA5 | ENSP00000261007 | ENSP00000299565 | Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | 0.717 |
CHRNA1 | CHRNA7 | ENSP00000261007 | ENSP00000407546 | Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. | 0.618 |
CHRNA1 | CHRNB2 | ENSP00000261007 | ENSP00000357461 | Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | Neuronal acetylcholine receptor subunit beta-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions. | 0.762 |