node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAP1 | AGFG2 | ENSP00000158762 | ENSP00000300176 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration. | Arf-GAP domain and FG repeat-containing protein 2; ArfGAP with FG repeats 2. | 0.582 |
AGFG2 | ACAP1 | ENSP00000300176 | ENSP00000158762 | Arf-GAP domain and FG repeat-containing protein 2; ArfGAP with FG repeats 2. | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration. | 0.582 |
AGFG2 | DARS2 | ENSP00000300176 | ENSP00000497569 | Arf-GAP domain and FG repeat-containing protein 2; ArfGAP with FG repeats 2. | Aspartate--tRNA ligase, mitochondrial; aspartyl-tRNA synthetase 2, mitochondrial. | 0.490 |
AGFG2 | EPS15 | ENSP00000300176 | ENSP00000360798 | Arf-GAP domain and FG repeat-containing protein 2; ArfGAP with FG repeats 2. | Epidermal growth factor receptor substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internaliz [...] | 0.716 |
AGFG2 | EPS15L1 | ENSP00000300176 | ENSP00000393313 | Arf-GAP domain and FG repeat-containing protein 2; ArfGAP with FG repeats 2. | Epidermal growth factor receptor substrate 15-like 1; Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. | 0.867 |
AGFG2 | ITSN1 | ENSP00000300176 | ENSP00000370719 | Arf-GAP domain and FG repeat-containing protein 2; ArfGAP with FG repeats 2. | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex. Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits. Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); inter [...] | 0.562 |
AGFG2 | MRPL46 | ENSP00000300176 | ENSP00000312311 | Arf-GAP domain and FG repeat-containing protein 2; ArfGAP with FG repeats 2. | Mitochondrial ribosomal protein L46; Belongs to the mitochondrion-specific ribosomal protein mL46 family. | 0.550 |
AGFG2 | MRPS5 | ENSP00000300176 | ENSP00000272418 | Arf-GAP domain and FG repeat-containing protein 2; ArfGAP with FG repeats 2. | Mitochondrial ribosomal protein S5; Belongs to the universal ribosomal protein uS5 family. | 0.529 |
AGFG2 | NUMBL | ENSP00000300176 | ENSP00000252891 | Arf-GAP domain and FG repeat-containing protein 2; ArfGAP with FG repeats 2. | Numb-like protein; Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B ac [...] | 0.495 |
AGFG2 | RANBP6 | ENSP00000300176 | ENSP00000259569 | Arf-GAP domain and FG repeat-containing protein 2; ArfGAP with FG repeats 2. | Ran-binding protein 6; May function in nuclear protein import as nuclear transport receptor. | 0.562 |
AGFG2 | TIMM10B | ENSP00000300176 | ENSP00000254616 | Arf-GAP domain and FG repeat-containing protein 2; ArfGAP with FG repeats 2. | Mitochondrial import inner membrane translocase subunit Tim10 B; Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space. | 0.543 |
DARS2 | AGFG2 | ENSP00000497569 | ENSP00000300176 | Aspartate--tRNA ligase, mitochondrial; aspartyl-tRNA synthetase 2, mitochondrial. | Arf-GAP domain and FG repeat-containing protein 2; ArfGAP with FG repeats 2. | 0.490 |
DARS2 | MRPL46 | ENSP00000497569 | ENSP00000312311 | Aspartate--tRNA ligase, mitochondrial; aspartyl-tRNA synthetase 2, mitochondrial. | Mitochondrial ribosomal protein L46; Belongs to the mitochondrion-specific ribosomal protein mL46 family. | 0.482 |
DARS2 | MRPS5 | ENSP00000497569 | ENSP00000272418 | Aspartate--tRNA ligase, mitochondrial; aspartyl-tRNA synthetase 2, mitochondrial. | Mitochondrial ribosomal protein S5; Belongs to the universal ribosomal protein uS5 family. | 0.689 |
DARS2 | RANBP6 | ENSP00000497569 | ENSP00000259569 | Aspartate--tRNA ligase, mitochondrial; aspartyl-tRNA synthetase 2, mitochondrial. | Ran-binding protein 6; May function in nuclear protein import as nuclear transport receptor. | 0.495 |
EPS15 | AGFG2 | ENSP00000360798 | ENSP00000300176 | Epidermal growth factor receptor substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internaliz [...] | Arf-GAP domain and FG repeat-containing protein 2; ArfGAP with FG repeats 2. | 0.716 |
EPS15 | EPS15L1 | ENSP00000360798 | ENSP00000393313 | Epidermal growth factor receptor substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internaliz [...] | Epidermal growth factor receptor substrate 15-like 1; Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. | 0.990 |
EPS15 | ITSN1 | ENSP00000360798 | ENSP00000370719 | Epidermal growth factor receptor substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internaliz [...] | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex. Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits. Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); inter [...] | 0.997 |
EPS15 | NUMBL | ENSP00000360798 | ENSP00000252891 | Epidermal growth factor receptor substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internaliz [...] | Numb-like protein; Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B ac [...] | 0.987 |
EPS15L1 | AGFG2 | ENSP00000393313 | ENSP00000300176 | Epidermal growth factor receptor substrate 15-like 1; Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. | Arf-GAP domain and FG repeat-containing protein 2; ArfGAP with FG repeats 2. | 0.867 |