node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASPHD1 | C16orf54 | ENSP00000311447 | ENSP00000327506 | Aspartate beta-hydroxylase domain containing 1. | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | 0.803 |
ASPHD1 | C16orf92 | ENSP00000311447 | ENSP00000300575 | Aspartate beta-hydroxylase domain containing 1. | Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92. | 0.679 |
ASPHD1 | DOC2A | ENSP00000311447 | ENSP00000482870 | Aspartate beta-hydroxylase domain containing 1. | Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. | 0.684 |
ASPHD1 | HIRIP3 | ENSP00000311447 | ENSP00000279392 | Aspartate beta-hydroxylase domain containing 1. | HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. | 0.693 |
ASPHD1 | INO80E | ENSP00000311447 | ENSP00000457016 | Aspartate beta-hydroxylase domain containing 1. | INO80 complex subunit E; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. | 0.678 |
ASPHD1 | KCTD13 | ENSP00000311447 | ENSP00000455785 | Aspartate beta-hydroxylase domain containing 1. | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission. The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission (By similarity). Belongs to the BACURD family. | 0.814 |
ASPHD1 | PAGR1 | ENSP00000311447 | ENSP00000326519 | Aspartate beta-hydroxylase domain containing 1. | PAXIP1-associated glutamate-rich protein 1; Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switchin [...] | 0.634 |
ASPHD1 | SEZ6L2 | ENSP00000311447 | ENSP00000481917 | Aspartate beta-hydroxylase domain containing 1. | Seizure 6-like protein 2; May contribute to specialized endoplasmic reticulum functions in neurons; Belongs to the SEZ6 family. | 0.869 |
ASPHD1 | TMEM219 | ENSP00000311447 | ENSP00000457492 | Aspartate beta-hydroxylase domain containing 1. | Insulin-like growth factor-binding protein 3 receptor; Cell death receptor specific for IGFBP3, may mediate caspase- 8-dependent apoptosis upon ligand binding. | 0.632 |
ASPHD1 | YPEL3 | ENSP00000311447 | ENSP00000381821 | Aspartate beta-hydroxylase domain containing 1. | Protein yippee-like 3; Involved in proliferation and apoptosis in myeloid precursor cells. | 0.687 |
C16orf54 | ASPHD1 | ENSP00000327506 | ENSP00000311447 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | Aspartate beta-hydroxylase domain containing 1. | 0.803 |
C16orf54 | C16orf92 | ENSP00000327506 | ENSP00000300575 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92. | 0.692 |
C16orf54 | DOC2A | ENSP00000327506 | ENSP00000482870 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. | 0.600 |
C16orf54 | HIRIP3 | ENSP00000327506 | ENSP00000279392 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. | 0.664 |
C16orf54 | INO80E | ENSP00000327506 | ENSP00000457016 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | INO80 complex subunit E; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. | 0.596 |
C16orf54 | KCTD13 | ENSP00000327506 | ENSP00000455785 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission. The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission (By similarity). Belongs to the BACURD family. | 0.601 |
C16orf54 | PAGR1 | ENSP00000327506 | ENSP00000326519 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | PAXIP1-associated glutamate-rich protein 1; Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switchin [...] | 0.594 |
C16orf54 | SEZ6L2 | ENSP00000327506 | ENSP00000481917 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | Seizure 6-like protein 2; May contribute to specialized endoplasmic reticulum functions in neurons; Belongs to the SEZ6 family. | 0.609 |
C16orf54 | TMEM219 | ENSP00000327506 | ENSP00000457492 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | Insulin-like growth factor-binding protein 3 receptor; Cell death receptor specific for IGFBP3, may mediate caspase- 8-dependent apoptosis upon ligand binding. | 0.661 |
C16orf54 | YPEL3 | ENSP00000327506 | ENSP00000381821 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. | Protein yippee-like 3; Involved in proliferation and apoptosis in myeloid precursor cells. | 0.600 |