node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCL21 | KLHL26 | ENSP00000259607 | ENSP00000300976 | C-C motif chemokine 21; Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. | Kelch-like protein 26; Kelch like family member 26. | 0.595 |
CIB3 | ERICH3 | ENSP00000269878 | ENSP00000322609 | Calcium and integrin binding family member 3. | Glutamate-rich protein 3; Glutamate rich 3. | 0.432 |
CIB3 | KLHL26 | ENSP00000269878 | ENSP00000300976 | Calcium and integrin binding family member 3. | Kelch-like protein 26; Kelch like family member 26. | 0.517 |
CIB3 | ODF3L2 | ENSP00000269878 | ENSP00000318029 | Calcium and integrin binding family member 3. | Outer dense fiber of sperm tails 3 like 2. | 0.521 |
CUL3 | IPP | ENSP00000264414 | ENSP00000379739 | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...] | Actin-binding protein IPP; May play a role in organizing the actin cytoskeleton. | 0.614 |
CUL3 | KLHL12 | ENSP00000264414 | ENSP00000356230 | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...] | Kelch-like protein 12; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts w [...] | 0.999 |
CUL3 | KLHL26 | ENSP00000264414 | ENSP00000300976 | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...] | Kelch-like protein 26; Kelch like family member 26. | 0.694 |
CUL3 | KLHL28 | ENSP00000264414 | ENSP00000347193 | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...] | Kelch-like protein 28; Kelch like family member 28. | 0.613 |
ERICH3 | CIB3 | ENSP00000322609 | ENSP00000269878 | Glutamate-rich protein 3; Glutamate rich 3. | Calcium and integrin binding family member 3. | 0.432 |
ERICH3 | KLHL26 | ENSP00000322609 | ENSP00000300976 | Glutamate-rich protein 3; Glutamate rich 3. | Kelch-like protein 26; Kelch like family member 26. | 0.566 |
ERICH3 | ODF3L2 | ENSP00000322609 | ENSP00000318029 | Glutamate-rich protein 3; Glutamate rich 3. | Outer dense fiber of sperm tails 3 like 2. | 0.541 |
IPP | CUL3 | ENSP00000379739 | ENSP00000264414 | Actin-binding protein IPP; May play a role in organizing the actin cytoskeleton. | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...] | 0.614 |
IPP | KLHL26 | ENSP00000379739 | ENSP00000300976 | Actin-binding protein IPP; May play a role in organizing the actin cytoskeleton. | Kelch-like protein 26; Kelch like family member 26. | 0.523 |
IPP | KLHL28 | ENSP00000379739 | ENSP00000347193 | Actin-binding protein IPP; May play a role in organizing the actin cytoskeleton. | Kelch-like protein 28; Kelch like family member 28. | 0.710 |
KLHL12 | CUL3 | ENSP00000356230 | ENSP00000264414 | Kelch-like protein 12; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts w [...] | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...] | 0.999 |
KLHL12 | KLHL26 | ENSP00000356230 | ENSP00000300976 | Kelch-like protein 12; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts w [...] | Kelch-like protein 26; Kelch like family member 26. | 0.655 |
KLHL14 | KLHL26 | ENSP00000352314 | ENSP00000300976 | Kelch-like protein 14; Kelch like family member 14. | Kelch-like protein 26; Kelch like family member 26. | 0.519 |
KLHL14 | KLHL28 | ENSP00000352314 | ENSP00000347193 | Kelch-like protein 14; Kelch like family member 14. | Kelch-like protein 28; Kelch like family member 28. | 0.752 |
KLHL26 | CCL21 | ENSP00000300976 | ENSP00000259607 | Kelch-like protein 26; Kelch like family member 26. | C-C motif chemokine 21; Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. | 0.595 |
KLHL26 | CIB3 | ENSP00000300976 | ENSP00000269878 | Kelch-like protein 26; Kelch like family member 26. | Calcium and integrin binding family member 3. | 0.517 |