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ZFP28 protein (human) - STRING interaction network
"ZFP28" - Zinc finger protein 28 homolog in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ZFP28Zinc finger protein 28 homolog (mouse); May be involved in transcriptional regulation. May have a role in embryonic development (868 aa)    
Predicted Functional Partners:
TRIM28
Tripartite motif containing 28; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitm [...] (835 aa)
       
    0.901
POTEE
POTE ankyrin domain family member E (1075 aa)
     
 
  0.568
POTEI
POTE ankyrin domain family, member I (1075 aa)
     
 
  0.568
POTEJ
POTE ankyrin domain family, member J (1038 aa)
     
 
  0.568
POTEF
POTE ankyrin domain family, member F (1075 aa)
     
 
  0.568
RIPK4
Receptor-interacting serine-threonine kinase 4 (784 aa)
     
 
  0.509
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser-657’ of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser- 473’ of Akt triggers apoptosis an [...] (1323 aa)
     
 
  0.481
PHLPP1
PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on ’Ser-473’ of AKT2 and AKT3, ’Ser-660’ of PRKCB and ’Ser-657’ of PRKCA (PubMed-15808505, PubMed-17386267, PubMed-18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily [...] (1717 aa)
     
 
  0.481
LRRK2
Leucine-rich repeat kinase 2; Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (C [...] (2527 aa)
     
 
  0.415
ARR3
Arrestin 3, retinal (X-arrestin); May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins (388 aa)
       
 
  0.403
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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