node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTR1A | ACTR1B | ENSP00000358921 | ENSP00000289228 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | 0.992 |
ACTR1A | OTP | ENSP00000358921 | ENSP00000302814 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells. | 0.666 |
ACTR1B | ACTR1A | ENSP00000289228 | ENSP00000358921 | Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | 0.992 |
ACTR1B | OTP | ENSP00000289228 | ENSP00000302814 | Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells. | 0.675 |
ARNT2 | OTP | ENSP00000307479 | ENSP00000302814 | Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE). | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells. | 0.619 |
ARNT2 | POU3F2 | ENSP00000307479 | ENSP00000329170 | Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE). | POU domain, class 3, transcription factor 2; Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL [...] | 0.528 |
ARNT2 | SIM1 | ENSP00000307479 | ENSP00000358210 | Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE). | Single-minded homolog 1; Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. | 0.979 |
ARNT2 | SIM2 | ENSP00000307479 | ENSP00000290399 | Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE). | Single-minded homolog 2; Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. | 0.904 |
OTP | ACTR1A | ENSP00000302814 | ENSP00000358921 | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells. | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | 0.666 |
OTP | ACTR1B | ENSP00000302814 | ENSP00000289228 | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells. | Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | 0.675 |
OTP | ARNT2 | ENSP00000302814 | ENSP00000307479 | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells. | Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE). | 0.619 |
OTP | OXT | ENSP00000302814 | ENSP00000217386 | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells. | Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin. | 0.742 |
OTP | PAX2 | ENSP00000302814 | ENSP00000359319 | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells. | Paired box protein Pax-2; Transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS. | 0.588 |
OTP | POU3F2 | ENSP00000302814 | ENSP00000329170 | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells. | POU domain, class 3, transcription factor 2; Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL [...] | 0.789 |
OTP | SIM1 | ENSP00000302814 | ENSP00000358210 | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells. | Single-minded homolog 1; Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. | 0.863 |
OTP | SIM2 | ENSP00000302814 | ENSP00000290399 | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells. | Single-minded homolog 2; Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. | 0.582 |
OTP | SIX3 | ENSP00000302814 | ENSP00000260653 | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells. | Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...] | 0.635 |
OTP | TRH | ENSP00000302814 | ENSP00000303452 | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells. | Pro-thyrotropin-releasing hormone; As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes. | 0.562 |
OXT | OTP | ENSP00000217386 | ENSP00000302814 | Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin. | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells. | 0.742 |
OXT | POU3F2 | ENSP00000217386 | ENSP00000329170 | Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin. | POU domain, class 3, transcription factor 2; Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL [...] | 0.567 |